Hydrogel entrapping therapeutic agent and stent with coating...

Details Hydrogel entrapping therapeutic agent and stent with coating... Hydrogel entrapping therapeutic agent and stent with coating...

2005-06-14

2005-06-14

Nutter, Nathan M. (Department: 1711)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C424S484000, C424S486000, C424S487000, C424S488000, C523S105000, C525S937000, C602S048000, C604S048000

Reexamination Certificate

active

06905700

ABSTRACT:
A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom. In one embodiment, a vascular stent is coated with hydrogel with therapeutic agent entrapped therein.

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