Hydrogel compositions and methods of use

Details Hydrogel compositions and methods of use Hydrogel compositions and methods of use

1992-08-07

1996-05-07

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424486, 424488, 424484, 2523151, 2523153, 514944, A61K 910, A61K 4900, A61K 4904

Patent

active

055143792

ABSTRACT:
Biocompatible, biodegradable, hydrogels are prepared from a backbone bonded to a cross-linking agent. Suitable backbones include proteins and polysaccharides, e.g,, albumin, polymannuronic acid, or polygalacturonic acid. Suitable cross-linking agents include polyvalent derivatives of polyethylene or polyalkylene glycol. These hydrogel compositions may be loaded with diagnostic labels, e.g,, radiopaque, paramagnetic, or superparamagnetic materials, or therapeutic drugs, e.g., chemotherapeutic drugs, antibiotics, or cells that produce therapeutic agents. This invention also relates to methods of use of such hydrogels for imaging during interventional procedures of a patient.

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