Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1990-06-04
1991-05-21
Raymond, Richard L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C07C21142
Patent
active
050177249
ABSTRACT:
Novel hydrofluorene derivatives and salts thereof represented by the formula (1) which possess excellent activities for improving anoxemic and hypoxic symptoms and syndromes accompanied therewith, therefore said derivatives are useful as cerebral activators, preventive agents for arrhythmia and heart failure caused by the shortage of oxygen and others. Furthermore, said hydrofluorene derivatives and salts thereof possess actions for scavenging active oxygen radicals, therefore, the derivatives are useful prophylactic and treating agents for various disturbances and diseases caused by the excessive formation of active oxygen radicals. In addition to the above, the hydrofluorene derivatives are useful as anti-oxidative agents for fats and oils.
Yet, further, the hydrofluorene derivatives and salts thereof accelerate the uptaking of high-affinity choline in the central nerve system and/or the releasing of acetylcholine therefrom, therefore, the hydrofluorene derivatives and salts thereof are useful cholinergic nerve system activating agents.
REFERENCES:
patent: 3010972 (1961-11-01), Kaiser et al.
patent: 3159677 (1964-12-01), Godefroi
patent: 3553267 (1971-01-01), Ward
patent: 4113726 (1978-09-01), Hauck et al.
patent: 4788130 (1988-11-01), Oshiro et al.
patent: 4792628 (1988-12-01), Oshiro et al.
Oshiro Yasuo
Sakurai Yoji
Sato Seiji
Tanaka Tatsuyoshi
Bembenick Brian
Otsuka Pharmaceutical Co. Ltd.
Raymond Richard L.
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