Hydrochlorides of chlorides of 2-aminoalkyl-9-hydroxy-ellipticin

Details Hydrochlorides of chlorides of 2-aminoalkyl-9-hydroxy-ellipticin Hydrochlorides of chlorides of 2-aminoalkyl-9-hydroxy-ellipticin

1986-06-24

1990-01-30

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 70, A61K 31475

Patent

active

048973980

ABSTRACT:
The invention relates to the 2-aminoalkyl-9-hydroxyellipticinium chloride hydrochloride of formula: ##STR1## in which Z represents hydrogen or a lower alkyl group, Alk represents a lower alkylene group and Am represents a di(lower alkyl)amino, pyrrolidino or piperidino group.
These compounds are useful as antitumour agents.

REFERENCES:
patent: 4310667 (1982-12-01), Le Pecq et al.
patent: 4816462 (1989-03-01), Nowicky
Proc. Am. Assn for Cancers Res, 73rd meeting, Abstract 593 (1982).
Proc. Am. Assn For Cancer Res. 74th meeting, Absract 656 (1983).
Proc. Am. Assn for Cancer Res. 80th meeting, Abstr. 996(1989).
Auclair et al., Cancer Res., vol. 47, pp. 6254-6261 (1987).
NCI-EORTC Symposium, 1989, Abstracts 435, 436.
Husson, et al., Chem. Abstracts, vol. 97 (1982), entry 6598.
Chemical Abstracts No. 97:6608d; Husson et al.; vol. 97, 1982, p. 638.

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