Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-05-24
1995-05-02
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D40502
Patent
active
054120969
ABSTRACT:
Hydrochloride salts of heterocyclic spiro compounds are provided and can be represented by the following general formula: ##STR1## wherein A represents piperidine or N alkyl piperidine or N alkylene attached to a non adjacent piperidine ring carbon, X is S or O, Y is carbonyl, thiocarbonyl, methylene, R.sup.5 methylene, ##STR2## alk in which R.sup.1 to R.sub.3,R.sub.6,R.sub.7 are H or alkyl, R.sub.4 is H, alkyl, COOH, or ester, or --C alkyl, R.sub.5 is halo, OH,SH, O alkyl, S alkyl, O acyl or S acyl, and Z, and Z.sub.2 are O or S. The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.
REFERENCES:
patent: Re34653 (1994-07-01), Tsukamoto et al.
patent: 4940795 (1990-07-01), Tsukamoto et al.
patent: 5041549 (1991-08-01), Tsukamoto et al.
Harada Masatomi
Nagaoka Hitoshi
Tamura Toshinari
Tsukamoto Shin-ichi
Usuda Shinji
Daus Donald G.
Yamanouchi Pharmaceutical Co. Ltd.
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