Hydrochloride salts of a glycopeptide phosphonate derivative

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Peptides with at least one nonpeptide bond other than a...

Reexamination Certificate

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C530S317000

Reexamination Certificate

active

08003755

ABSTRACT:
Disclosed are hydrochloride salts of telavancin having a chloride ion content of from about 2.4 wt. % to about 4.8 wt. %. The disclosed salts have improved stability during storage at ambient temperatures compared to other hydrochloride salts. Also disclosed are processes for preparing such salts.

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Diana et al., “Development and validation of an improved method for the analysis of vancomycin by liquid chromatography; Selectivity of reversed-phase columns towards vancomycin components”, Journal of Chromatography A, 996, pp. 115-131 (2003).
“Telavancin Hydrochloride”, Drugs of the Future 2004, 29(12): pp. 1211-1219 (2004).

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