Hydroaminomethylation of olefins

Details Hydroaminomethylation of olefins Hydroaminomethylation of olefins

2007-05-22

2007-05-22

Parsa, J. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S467000, C544S178000, C548S579000

Reexamination Certificate

active

11040762

ABSTRACT:
The present invention relates to a method comprising the step of contacting under hydroaminomethylation conditions, an olefin, an amine, a rhodium-phosphorous ligand, and synthesis gas (syngas). In particular, it has been discovered that, under some circumstances, a neutral rhodium-monodentate phosphite ligand is prescribed. The invention provides a simple way of making, in high yields and regiospecificity, a variety of products, including pharmacologically active products such as ibutilide, terfenadine, and fexofenadine, and derivatives thereof.

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