Hydrazonopyrazole derivatives and their use as therapeutics

Details Hydrazonopyrazole derivatives and their use as therapeutics Hydrazonopyrazole derivatives and their use as therapeutics

2011-01-25

2011-01-25

Havlin, Robert (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S407000

Reexamination Certificate

active

07875728

ABSTRACT:
Pharmaceutical compositions and compounds are provided. The compounds of the invention demonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, pharmaceutical compositions of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical compositions are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.

REFERENCES:
patent: 4006127 (1977-02-01), Raue et al.
patent: 4562248 (1985-12-01), Weaver et al.
patent: 6214813 (2001-04-01), Zhang et al.
patent: 6436915 (2002-08-01), Zhang et al.
patent: 2003/0060453 (2003-03-01), Zhang et al.
patent: 955085 (1964-04-01), None
patent: 1139361 (1969-01-01), None
patent: WO 01/56557 (2001-08-01), None
patent: WO 01/56993 (2001-08-01), None
patent: WO 01/57022 (2001-08-01), None
patent: WO 01/77080 (2001-10-01), None
patent: WO 02/062804 (2002-08-01), None
patent: WO 03/045379 (2003-06-01), None
patent: WO 03/055860 (2003-07-01), None
CAPLUS abstract Accession # 1989:407356 (Sadek et al. (Liebigs Annalen der Chemie (1989), (5), 501-2).
“Guidance for Industry, Q3C Impurities: Residual Solvents”, FDA, Dec. 1997.
Gompper et al, Angew. Chem. Int. Ed. Engl. 24 (1985) No. 11, p. 984-985.
Baig, G., et al., “Triazines and Related Products Part 24. Synthesis of Pyrazol-4-ylidenehydrazinoimidazoles by Hrdrazinolysis of Imidazo [5,1-c] [1,2,4]-triazines t and 2-Arylazoimidazoles by Diazonium Coupling Reactions,”Journal of the Chemical Society, Perkin Transactions 1(8), 1811-1819, 1982.
Dawood, K., et al., “Heterocyclic Synthesis via Enaminonitriles: A Convenient Route to Some New Pyrazole, Isoxazole, Pyrimidine, Pyrazolo[1,5-a]pyrimidine, Pyrimido [1,2-a]benzimidazole and Pyrido[1,2-a]benzimidazole Derivatives,”J. Chem. Res.(S):208-209, 1998.
El-Gaby, M., et al., “Preparation of Some Novel 3,5-Diaminopyrazole, pyrazolo-[1,5-a] [1,3,5]Triazine and Pyrazolo [1,5-a]-Pyrimidine Derivatives Containing Sulfonamido Moieties as Antimicrobial Agents,”Acta. Chim. Slov., 19:159-171, 2002.
Elgemeie, G., et al., “Novel Synthesis of Mercaptopurine and Pentaaza-as-Indacene Analogues: Reaction of [Bis(methylthio)methylene]malononitrile and Ethyl 2-Cyano-3, 3-bis(methylthio)acrylate with 5-Aminopyrazoles,”Bull. Chem. Soc. Jpn., 67(3):738-741, 1994.
Elnagdi, M., et al., “Reactions with Heterocyclic Diazonium Salts: Novel Synthesis of Pyrazolo[4,3-c]pyridazines and of Pyrazolo[4,3-c]pyrazoles,”Journal of the Chemical Society, Perkin Transactions 1(4):989-991, 1982.
Hanna, M., et al., “Novel Anchored Nitrogen-containing Heterocycles of Potential Biological Activity from 2,3-dioxobutanethioanilide 2-arylhydrazone,”Chem. Papers, 43(5):651-659, 1989.
Hassan, A., “Chemical Interactions Between Aminopyrazoles and 2,3-Dicyano-1,4-naphthoquinone,”Liebigs Annalen der Chemie, 6:695-697, 1993.
Kandel, Z., et al., “Activated Nitriles in Heterocyclic Synthesis: Reaction of Cyanogen Bromide with some Functionally Substituted Enamines,”Journal of the Chemical Society, Perkin Transactions 1, pp. 1499-1502, 1985.
Mourad, A-F., et al., “Pyrimidine Derivatives and Related Compounds: Synthesis of new 3-(2,3-Dimethyl-5-oxo-1-phenyl-pyrazolin-4-yl)-azopyrazolo[1,5-a]pyrimidines,”Archiv Der Pharmazie, 317(3):241-5, 1984.
Nawwar, G., et al., “Synthesis of 2-Substituted Benzothiazoles Containing Amino Acid, Imino or Heteroaryl Moieties with Anticipated Fungicidal Activity,”Collect. Czech. Chem. Commun., 60:2200-2208, 1995.
Schafer, H., et al., “Substituierte 4-Nitropyrazole aus Nitroketenaminalen,”J. f. Prakt. Chemie., 323(2):332-336, 1981.
Chemical Abstracts, vol. 68, No. 11, Abstract No. 49503j, 1968.
World Patent Index (Thomson Derwent), Database Accession No. 1977-75291Y, 1977.
CHEMCATS Database (Chemical Abstracting Service), Database Accession Nos. 2002:1111382, 2002:1110659, 2002:935464, 2002:933931, 2001:2659752, Jan. 21, 2002.
CHEMCATS Database (Chemical Abstracting Service), Database Accession Nos. 2002:1409323 and 2001:1349750, Jul. 1, 2001.
CHEMCATS Database (Chemical Abstracting Service), Database Accession No. 2002:144647, Feb. 11, 2002.
CHEMCATS Database (Chemical Abstracting Service), Database Accession Nos. 2002:2994140 and 2002:638291, Jan. 17, 2002.
CHEMCATS Database (Chemical Abstracting Service), Database Accession Nos. 2002:820781 and 2002:3111028, Oct. 4, 2002.
CHEMCATS Database (Chemical Abstracting Service), Database Accession No. 2002:3207695, Mar. 22, 2001.
CHEMCATS Database (Chemical Abstracting Service), Database Accession Nos. 2002:2774951, 2002:2774930, 2002:2021345, 2002:2021344, 2002:1828293, 2002:1975388, 2002:1828294, Jul. 9, 2002.
Chemical Abstracts Database, Accession No. 2000:41863, 2000.
Chemical Abstracts Database, Accession No. 1995:954284, 1995.
Chemical Abstracts Database, Accession No. 1970:414400, 1970.
Chemical Abstracts Database, Accession No. 1996:12389, 1996.
Chemical Abstracts Database, Accession No. 1994:54519, 1994.
Chemical Abstracts Database, Accession No. 1978:443341, 1978.
Chemical Abstracts Database, Accession No. 1975:72860, 1975.
Chemical Abstracts Database, Accession No. 1974:82349, 1974.
Chemical Abstracts Database, Accession No. 1994:409222, 1994.
Chemical Abstracts Database, Accession No. 1974:108415, 1974.
Chemical Abstracts Database, Accession No. 2000:530709, 2000.
Chemical Abstracts Database, Accession No. 1969:422058, 1969.
Chemical Abstracts Database, Accession No. 1986:5847, 1986.
Chemical Abstracts Database, Accession No. 1984:551788, 1984.
Chemical Abstracts Database, Accession No. 1994:164052, 1994.
Chemical Abstracts Database, Accession No. 1978:509222, 1978.
Chemical Abstracts Database, Accession No. 1965:463025, 1965.
Chemical Abstracts Database, Accession No. 1986:50853, 1986.
Chemical Abstracts Database, Accession No. 1990:139004, 1990.
Chemical Abstracts Database, Accession No. 1986:148149, 1986.
Chemical Abstracts Database, Accession No. 1999:87103, 1999.
Chemical Abstracts Database, Accession No. 1987:477760, 1987.
Chemical Abstracts Database, Accession No. 1985:541920, 1985.
Behr, L., et al.,Pyrazoles, Pyrazolines, Pyrazolidines, Indazoles and Condensed Rings, (Wiley, R. ed.), Interscience Publishers, New York, 1967, Ch. 2, “Tautomerism and Isomerism,” pp. 4-9.
Delcommenne, M., et al., “Phosphoinositide-3-OH Kinase-dependent Regulation of Glycogen Synthase kinase 3 and Protein Kinase B/AKT by the Integrin-linked Kinase,”Proc Natl Acad Sci U S A., 95(19):11211-6, Sep. 15, 1998.
Golub, T., et al; “Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring,”Science, 286(5439):531-7, Oct. 15, 1999.
Chemical Abstracts, vol. 64, Abstract No. 5068f, 1966.
Chemical Abstracts, vol. 82, Abstract No. 66061v, 1975.
Chemical Abstracts, vol. 105, Abstract No. 191071, 1986.
Chemical Abstracts Database, Accession No. 1994:323476, 1994.
Chemical Abstracts Database, Accession No. 1968:418743, 1968.
Chemical Abstracts Database, Accession No. 1988:131679, 1988.
Chemical Abstracts Database, Accession No. 1979:439437, 1979.
Chemical Abstracts Database, Accession No. 1973:478677, 1973.
Chemical Abstracts Database, Accession No. 1984:530079, 1984.
Chemical Abstracts Database, Accession No. 1994:8545, 1994.
Chemical Abstracts Database, Accession No. 1982:562888, 1982.
Cea et al., “Compuestos Interlaminares Coordinados de Cianuro de Niguel con Aminas Alifaticas,” Anales de Quimica 81(1): 11-17, 1985.
El-Haty et al., “Solvent and pH effects on the electronic spectra of some 4-arylazo-3,5-diaminopyrazoles,” Bull Soc Chim Fr 128: 869-872, 1991.
Elagamey et al., “Nitriles in heterocyclic synthesis: synthesis of pyrazolo[1,5-a] pyrimidine, pyrazolo[1,5-c] [1

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