Hydrazones

Details Hydrazones Hydrazones

1994-11-30

1995-10-24

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514582, 514590, 514601, 514602, 514603, 514631, 514639, 564 19, 564 36, 564 80, 564 81, 564225, 564226, 564227, 564228, A61K 3115, A61K 31155, C07C28116

Patent

active

054610761

ABSTRACT:
Compounds of formula I ##STR1## wherein A, X, Z and R.sub.1 -R.sub.5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.

REFERENCES:
patent: 3956363 (1976-05-01), Shen et al.
patent: 4076726 (1978-02-01), Pannemann et al.
patent: 4080449 (1978-05-01), Crosier et al.
patent: 4971986, Stanek et al.
Chem Abst 104:207159v (1986) Corresponding to "AM" above.
Chem Abst 109:92791d (1988) Corresponding to CN 85 101 799 Jan. 17, 1987.
Chem Abst 1958, 14678a Corresponding to AP Above Jensch, DE 894693.
Chem Abst 105:6283c (1986). Gan et al. "Synthesis of Indanones and Tetralones as new potential Schistosomicidals," Yaoxue Xuebao 1985, 20(5) 342-52.
Misra et al, J. Indian Chem. Soc. vol. 52, Oct. 1975, pp. 981-982 "Synthesis and Antibacterial Activity of Thiosemicarbazones and Hydrazones Derived from Indanone-1".
Chem Abst 107:77634v (1987) Corresponding to WO 86 04582 Aug. 14, 1986 and U.S. application Ser. No. 700,375, filed Feb. 11, 1985.
Sam et al, J. Pharmacol. Sci. 53, 1364-1368 (1965) "Potential Antineoplastic Agents Derived from 1,2-Epoxylindan."
Chatterjea et al., J. Indian Chem Soc. 37, No. 8, 1960, pp. 443-450, "The Course of Cyclization of .beta.-Benzylhomophthalic Acids."
Juhani Janne et al, Biochem J. (1984) 218, 947-951 "Inhibition of S-adenosylmethionine decarboxylase and diamine oxidase activities by analogues of methylglyoxal bis(guanylhydrazone) and their cellular uptake during lymphocyte activation".
Patai (ed); "The Chemistry of Amidines and Imidates." Wiley & Sons, London 1975 pp. 303-304.
Williams-Ashman et al; Biochem. Biophys. Res. Commun. 46,288 (1972) "Methyl Glyoxal Bis(guanylhydrazone) as a Potent Inhibitor of Mammalian and Yeast S-adenosylmethionine Decarboxylases."
Dondoni; J. Chem. Soc. Chem. Commun. 1975, 761-762, "Synthetic Reactions using Transition Metal Complexes. Conversion of Amide Oximes into Amidines by Pentacarbonyliron and Evidence for Imine Intermediates in the Deoximation of Ketoximes".
Adamczyk et al; J. Org. Chem. 1984, 49 pp. 4226-4327 "Synthesis of Biological Markers in Fossil Fuels 2. Synthesis and .sup.13 C NMR Studies of Substituted Indans and Tetralins."
Miyake et al; Chem. Pharm. Bull. 31, (7), 2329-2348 (1983) "Synthesis of 2-(N-Substituted amino)-6-hydroxy-1,2,3,4-tetrahydronaphthalen-1-ol Derivatives".
Munavalli et al; Bull. Soc. Chim. France 1964 (12) pp. 3103-3112. "Synthese de derives indaniques." & corresponding Chem Abstr. 62:7702e-7703h.
Jackson et al; J. Chem. Soc. Perkin Trans. 1974, pp. 1911-1920. "Phenol Oxidation. Part III. Synthesis of the Benzylisoquinoline Alkaloid Cularine."
Bartmann et al; J. Heterocyclic Chem. 24, 677-682, 1987 "Synthesis of Di- and Tetraalkyl-3-piperazinoisoquinolines and Related Compounds as Potential Antidepressant Agents."
Sakar et al; Indian J. Chem., vol. 24B, Oct. 1985, pp. 1061-1064 "One-Step Preparation of Some Synthetically Useful Indanones."
Klein et al; J. Org. Chem., vol. 22, 1019-1021, Sep. 1957 "Synthesis of 8-Bromo-1-Methylnaphthalene from o-Bromoacetophenone."

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