Hydrazone derivatives and their use

Details Hydrazone derivatives and their use Hydrazone derivatives and their use

1991-03-15

1992-11-17

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514411, 514418, 546273, 548450, A61K 3144, A61K 3140, C07D20956, C07D21334

Patent

active

051644045

ABSTRACT:
A method of antagonizing the biological effects of an excitatory amino acid of a subject in need of such antagonization, comprising the step of administering to said subject an effective excitatory amino acid antagonizing amount of an indole-2,3-dione-3-hydrazone derivative, is disclosed. Certain of the compounds are novel. The compounds and pharmaceutical compositions containing the compounds are useful in the treatment of central nervous system disorders and especially conditions sensitive to excitatory amino acids.

REFERENCES:
patent: 4780477 (1988-10-01), Kobayashi et al.
patent: 4988710 (1991-01-01), Olney
Chemical Abstracts: CA 52: 11014-11015a.
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Copy of CAS On-Line File Registry for the compound 109725-61-3.
Copy of Beilstein On-Line Search Report for the CAS Registry number 109725-61-3 compound.

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