Hydrazinopyridazine compound, process for production thereof, an

Details Hydrazinopyridazine compound, process for production thereof, an Hydrazinopyridazine compound, process for production thereof, an

1984-03-22

1986-07-08

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544239, C07D23720, C07D23722, A61K 3150

Patent

active

045993335

ABSTRACT:
A hydrazinopyridazine compound represented by the formula ##STR1## wherein R.sup.1 represents a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a lower alkyl group which may optionally be substituted by a halogen atom or a hydroxyl, lower alkoxy, lower alkylthio, lower alkanoylamino, allyloxy or tetrahydrofurfuryloxy group, a lower alkoxy group which may optionally be substituted by a 2-furyl, phenyl or lower alkoxy group, a lower alkenyl group, a lower alkenyloxy group, or a lower alkynyl group; R.sup.2 represents a hydrogen atom, a halogen atom, a cyano group, a lower alkyl group which may optionally be substituted by a halogen atom or a lower alkoxy group, a lower alkoxy group, a lower alkenyl group, or a lower alkenyloxy group; R.sup.3, R.sup.4 and R.sup.5, independently from each other, represent a hydrogen atom, a halogen atom, a lower alkyl group which may optionally be substituted by a lower alkoxy group, or a lower alkoxy group; R.sup.6 and R.sup.7, independently from each other, represent a hydrogen atom or a methyl group; Y represents --NH.sub.2, --NH--COOC.sub.2 H.sub.5, or ##STR2## Z represents --O--, --S--, or ##STR3## in which R.sup.8 represents a hydrogen atom or a lower alkyl group; and n is 1 or 2, or its salt; a process for the production the aforesaid compounds; and use of such compounds as antihypertensive agents.

REFERENCES:
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patent: 3723524 (1973-03-01), Augstein et al.
patent: 3891641 (1975-06-01), Pifferi
patent: 4027027 (1977-05-01), Jaeggi et al.
patent: 4115575 (1978-09-01), Frei et al.
patent: 4324788 (1982-04-01), Dorigotti et al.

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