Hydrazide compounds with angiogenic activity

Details Hydrazide compounds with angiogenic activity Hydrazide compounds with angiogenic activity

2008-05-06

2010-11-23

Buttner, David (Department: 1796)

Stock material or miscellaneous articles

Composite

Of polyamide

C428S500000, C428S532000, C525S061000, C525S376000, C525S409000, C525S420000, C527S312000, C528S208000, C528S421000, C424S078080, C424S078170, C424S078180, C424S078360, C424S078370, C424S078380, C424S426000, C606S077000, C623S023750

Reexamination Certificate

active

07838122

ABSTRACT:
Compounds exhibiting angiogenic properties incorporating the structure of Formula I:in-line-formulae description="In-line Formulae" end="lead"?R3—NH—NH—C(═O)—R2—P—R1  (I)in-line-formulae description="In-line Formulae" end="tail"?wherein P is a water-soluble, biodegradable polymer, R1is hydrogen, lower alkyl, lower alkoxy or —R2—C(═O)—NH—NH—R3; each R2is independently —CH2—, —NH— or O; and each R3is independently hydrogen or a residue of a naturally occurring alpha-L-amino acid or dipeptide thereof. Polymer networks crosslinked with hydrazide compounds are also disclosed, together with implantable medical devices incorporating the compounds and crosslinked polymers, and angiogenesis-promoting treatment methods, including wound-treatment methods.

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