Hydrazide compounds with angiogenic activity

Stock material or miscellaneous articles – Composite – Of polyamide

Reexamination Certificate

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C428S500000, C428S532000, C525S061000, C525S376000, C525S409000, C525S420000, C527S312000, C528S208000, C528S421000, C424S078080, C424S078170, C424S078180, C424S078360, C424S078370, C424S078380, C424S426000, C606S077000, C623S023750

Reexamination Certificate

active

07838122

ABSTRACT:
Compounds exhibiting angiogenic properties incorporating the structure of Formula I:in-line-formulae description="In-line Formulae" end="lead"?R3—NH—NH—C(═O)—R2—P—R1  (I)in-line-formulae description="In-line Formulae" end="tail"?wherein P is a water-soluble, biodegradable polymer, R1is hydrogen, lower alkyl, lower alkoxy or —R2—C(═O)—NH—NH—R3; each R2is independently —CH2—, —NH— or O; and each R3is independently hydrogen or a residue of a naturally occurring alpha-L-amino acid or dipeptide thereof. Polymer networks crosslinked with hydrazide compounds are also disclosed, together with implantable medical devices incorporating the compounds and crosslinked polymers, and angiogenesis-promoting treatment methods, including wound-treatment methods.

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