Hydrazide and alkoxyamide angiogenesis inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S614000, C514S615000, C514S558000

Reexamination Certificate

active

06887863

ABSTRACT:
Compounds having the formulaare methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.

REFERENCES:
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patent: 9942436 (1999-08-01), None
patent: 9957098 (1999-11-01), None
Castro-Pichel, et al., “Synthesis & antiviral & cystatic activities,” Nucleos. & Nucleit. 9(7):985-1000 (1990).
Griffith, E.C., “Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin,” Chemistry and Biology 4(6):461-471 (1997).
Sin, Ny; “The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2,” Proc. National Academy of Science USA 94:6099-6103 (1997).

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