Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1974-11-25
1978-02-07
Morgenstern, Norman
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
260287T, 26029372, 2603131, 2603261, 260453AR, 260520C, 424258, 424267, 424274, 424317, 560 56, 560 59, 560 62, 560 63, C07C 6514, C07C 6976, A61K 3119, A61K 31235
Patent
active
040727548
ABSTRACT:
Hydratropic acid derivatives of the formula ##STR1## wherein R.sub.1 is H, alkyl of 1-4 carbon atoms, 2-acetamidoethyl, 1-methyl-4-piperidyl, or 2,3-dihydroxypropyl, and R.sub.2 is Hal, phenyl, 4-Hal-phenyl, 4-Hal-phenoxy, 4-Hal-phenoxymethyl, 1,2,3,4-tetrahydro-1-naphthyl, 1-pyrryl, piperidino, isoindolino, 1,2,3,4-tetrahydroquinolino, 1,2,3,4-tetrahydro-4-quinolyl or 1-methyl-1,2,3,4-tetrahydro-4-quinolyl, Hal being F, Cl, or Br, and the physiologically acceptable salts thereof, which possess cholesterol and triglyceride serum-level-lowering activity, can be prepared by reacting a phenol of the formula ##STR2## with a compound of the formula X--C(CH.sub.3)(C.sub. 6 H.sub.5)--COOR.sub.1 wherein X represents Cl, Br, I, OH, or esterified OH.
REFERENCES:
patent: 3517051 (1970-06-01), Bolhofer
patent: 3641110 (1972-02-01), Beneze
patent: 3707549 (1972-12-01), Mills
patent: 3755603 (1973-08-01), Harrison et al.
Yale, Journal of Medicinal & Pharmaceutical Chemistry, vol. 1 (2), 1959, p. 1.
Kayser Detlev
Mehrhof Werner
Nowak Herbert
Schacht Erich
Simane Zdenek
Merck Patent Gesellschaft mit beschrankter Haftung
Morgenstern Norman
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