Hydrate of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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07045633

ABSTRACT:
A hydrate of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, maleic acid salt, characterized in that it: (i) comprises water in the range of from 0.2 to 1.1% w/w; and (ii) provides an infrared spectrum containing peaks at 764 and 579 cm−1; and/or (iii) provides an X-ray powder diffraction (XRPD) pattern substantially as set out in FIG. II; a process for the preparation of such a compound, a pharmaceutical composition containing such a compound and the use of such a compound or composition in medicine.

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Cantello, et al., “The Synthesis of BRL 49653—A Novel and Potent Antihyperglycaemic Agent”.Bioorganic&Medicinal Chemistry Letters, 4(10): 1181-1184 (1994).
Haleblian, et al., “Pharmaceutical Applications of Polymorphism”.Journal of Pharmaceutical Sciences, 58(8): 911-929 (1969).
Cantello, et al., “Facile Biocatalytic Reduction of the Carbon—Carbon Double Bond of 5-Benzylidenethiazolidine-2,4-diones. Synthesis of (+)-5-(4-[2-Methyl(2-pyridyl)amino]ethoxy benzyl)thiazolidine-2,4-dione (BRL 49653), its (R)-(+)-Enantiomer and Analogues”.J. Chem. Soc, Perkin Transactions 1, pp. 3319-3324 (1994).

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