Hydrate forms of alendronate sodium, processes for...

Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus acids or salts thereof

Reexamination Certificate

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C562S008000, C562S011000, C564S001000, C564S015000

Reexamination Certificate

active

06963008

ABSTRACT:
New hydrate forms of alendronate sodium, having water content of between about one and about twelve percent, and processes for their manufacture, are disclosed. New crystalline forms of alendronate sodium B, D, E, F, G and H, and processes for manufacturing them, are also disclosed. These new forms of alendronate sodium are suitable for incorporation into pharmaceutical compositions for combating bone resorption in bone diseases.

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Chem. abstr., vol. 125, No. 23, Dec. 2, 1996 (Columbus OH, USA), p. 1, col. 2, the abstract No. 291993b, Johnson, K.P., et al., ‘Management of Relapsing/Remitting Multiple Sclerosis with Copolymer (Copaxone).’ Mult. Scler. 1996, 1(6), 325-326 (Eng.), see entire document.
CA:83:147667 abs of Biopolymers by Murphy 14(7) pp. 1487-1501.
CA:90:95900 abs of Dok1, Akad, Nauk Az SSR by Dikareva 34(8) pp. 41-45.

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