Hydantoin derivatives with affinity for somatostatin receptors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S254050, C514S323000, C514S339000, C514S391000, C544S139000, C544S373000, C546S201000, C548S305100, C548S306100, C548S311400, C548S312100

Reexamination Certificate

active

07019004

ABSTRACT:
The invention provides compounds of formula (I) wherein X, Y, R1, R2, R3and R4are as defined in the description, and the preparation thereof. The compounds of the formula bind to somatostatin receptors and are useful as pharmaceuticals

REFERENCES:
patent: 5859190 (1999-01-01), Meyer et al.
patent: 2003/0191134 (2003-10-01), Shapiro et al.
patent: WO 01/09090 (2001-02-01), None
patent: 2003/042234 (2003-05-01), None
Yang, Annual Reports in Medicinal Chemistry, vol. 34, p. 209-218 (1999).
Sciciński et al., “The Solid Phase Synthesis of a Series of Tri-Substituted Hydantoin Ligands for the Somatostatin SST5Receptor”,Bioorg. Med. Chem. Lett., vol. 8, No. 24, pp. 3609-3614 (1998).

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