Hydantoin derivatives for treating complications of diabetes and

Details Hydantoin derivatives for treating complications of diabetes and Hydantoin derivatives for treating complications of diabetes and

1990-09-13

1992-11-17

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142325, 5142335, 514317, 514318, 514320, 514324, 514389, 544 70, 544230, 546 15, 5483011, C07D491107, A61K 31495, A61K 31415, A61K 31445

Patent

active

051643910

ABSTRACT:
The invention relates to a hydantoin derivative, salt thereof, process for the preparation thereof, and medicine containing the derivative. The derivative is represented by the formula ##STR1## wherein M is --CONH--NHR.sup.1 group, --CONH--OR.sup.2 group, ##STR2## in which R.sup.1 is hydrogen atom, an alkyl group, an alkenyl group, a phenyl radical, a substituted phenyl group, a naphthyl radical, a substituted naphthyl group, a pyridyl radical, a furyl radical or a thienyl radical, R.sup.2 is a hydrogen atom, an alkyl group, a phenyl radical or a substituted phenyl group, R.sup.3 and R.sup.4 are the same or different independently, each being a phenyl radical, or an aralkyl group, or R.sup.3 may form a substituted or non-substituted C.sub.5-6 saturated heterocyclic ring together with R.sup.4 and a possible nitrogen or oxygen atom, R.sup.5 forms a substituted or non-substituted saturated heterocyclic ring together with R.sup.6 and a possible nitrogen or oxygen atom, R.sup.7 is a nitroxy radical or a heteroaryl group, .sub.m and .sub.n are an integer of 2 to 5, Q is a hydrogen atom or ##STR3## in which R.sup.8 and R.sup.9 are the same or different independently, each being a substituted or non-substituted alkyl group, or R.sup.8 may form a substituted or non-substituted C.sub.5-6 saturated heterocyclic ring together with R.sup.9 and a possible nitrogen or oxygen atom, .sub.r is an integer of 2 to 5, T and X are the same or different independently, each being a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group or an alkylmercapto group, and Z is an oxygen or sulfur atom.
The derivatives and salts thereof are useful for the treatment of complications of diabetes and circulatory diseases.

REFERENCES:
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patent: 4780472 (1988-10-01), Ueda et al.
patent: 4861792 (1989-08-01), Kurono et al.
patent: 4978758 (1990-12-01), Kurono et al.
Kurono et al., Chemical Abstracts, vol. 106, No. 5042 (1987) (Abstract for EP 193415, Sep. 3, 1986).
Kinoshita et al.,, Jap. J. Ophthalmol. vol. 20: 399-410, 1976.
Gabbay, Int. Congr. Ser. Excerpta Med., 403,594 (1977).
Peterson et al., Metalbolism, vol. 28, No. 4, Suppl. 1 (Apr.), 1979.
Taguma et al., New England Journal of Medicine, vol. 313, No. 26, 1617, 1985.
Parying et al., British Medical Journal, vol. 294: 1443, 1987.

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