Hydantoin derivatives as aldose reductase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548309, 548311, A61K 31415, C07D23380

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active

049140990

ABSTRACT:
The present invention relates to novel hydantoin derivatives, processes for producing said hydantoin derivatives, pharmaceutical compositions containing at least one of said hydantoin derivatives as aldose reductase inhibitors and novel intermediate compounds in the synthesis of said hydantoin derivatives.
The present invention is based on the selection of a hydantoin which is bonded by a sulfonyl group to various substituents at the 1-position of the hydantoin skeleton.

REFERENCES:
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patent: 3534022 (1970-10-01), Umemoto et al.
patent: 4743611 (1988-05-01), Malamas et al.
Chemical Abstracts, vol. 95, No. 15, Oct. 12, 1981, Abstract No. 132725m.
Chemical Abstracts, vol. 97, No. 1, Jul. 5, 1982, Abstract No. 6774e.
Chemical Abstracts, vol. 99, 1983, Abstract No. 116079f.
Chemical Abstracts, vol. 107, 1987, Abstract No. 59037y.
Chemical Abstracts, vol. 109, 1988, Abstract No. 129004c.

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