Hydantoin derivatives, anti-diabetic compositions thereof, and m

Details Hydantoin derivatives, anti-diabetic compositions thereof, and m Hydantoin derivatives, anti-diabetic compositions thereof, and m

1980-05-27

1981-06-16

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546 18, C07D47120, A61K 3142

Patent

active

042737753

ABSTRACT:
A series of novel tetrahydroquinoline-derived spiro-hydantoin compounds has been prepared, including their pharmaceutically acceptable acid addition salts. These particular compounds are useful in therapy as aldose reductase inhibitors for the control of certain chronic diabetic complications. Preferred member compounds include 1'-methyl-1',2',3',4'-tetrahydro-spiro-[imidazolidine-4,4'-quinoline]-2,5- dione, 6'-chloro-1',2',3',4'-tetrahydro-spiro-[imidazolidine-4,4'-quinoline]-2,5- dione, 7'-chloro-1',2',3',4'-tetrahydro-spiro-[imidazolidine-4,4'-quinoline]-2,5- dione and 1'-methyl-1',2',3',4'-tetrahydro-spiro-[imidazolidine-4,4'-pyrido(2,3-b)py ridine]-2,5-dione. Methods for preparing these compounds from known starting materials are provided.

REFERENCES:
patent: 3821383 (1974-06-01), Sestanj et al.
Faust et al. "J. Am. Pharm. Assoc.", SCI. Ed., vol. 46, No. 2, pp. 118-124 (1957).

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