Hybridomas producing monoclonal antibodies which specifically bi

Details Hybridomas producing monoclonal antibodies which specifically bi Hybridomas producing monoclonal antibodies which specifically bi

1993-10-07

1995-10-17

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

53038822, 5303888, 4351722, 435 7021, C12N 520, C07K 1628, C07K 1630

Patent

active

054590612

ABSTRACT:
Hybridomas producing monoclonal antibodies that specifically bind to the human EGF receptor and compete with EGF for binding to the EGF receptor are described. The subject monoclonal antibodies bind to an epitope located between residues Ala-351 and Asp-364 of the EGF receptor, which is not denatured by boiling, treatment with detergent or treatment with a reducing agent.

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Ullrich et al. Nature 309:418 1984.
Appel et al. J. Immunology 144:976-983, 1990.
Dayhoff et al. "Atlas of Protein Sequence and Structure" vol. 5:89-99, 1972.

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