Hybridomas producing monoclonal antibodies to new mucin epitopes

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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4241551, 4241561, 4241571, 4241741, 435 7021, 4351722, 5303888, 53038885, 5303897, 5303913, 5303917, A61K 39395, C07K 1600

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058498761

ABSTRACT:
Novel hybridoma cell lines producing monoclonal antibodies reactive with purified mucin antigens from normal and tumor sources are generated using mucins, including purified mucins from tumor sources. Epitopes on mucin antigens from normal and tumor sources are demonstrated to be distinct, using these new antibodies. The antibodies may be useful alone or in combination, in the diagnosis and treatment of cancer including malignancies of the breast and lung.

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