Hybridomas producing monoclonal antibodies reactive with human t

Details Hybridomas producing monoclonal antibodies reactive with human t Hybridomas producing monoclonal antibodies reactive with human t

1988-03-09

1993-06-29

Nucker, Christine

Chemistry: molecular biology and microbiology

Spore forming or isolating process

530809, 53038825, 53038815, C12N 518, C07K 1528

Patent

active

052234274

ABSTRACT:
Murine hybridomas producing monoclonal antibodies capable of immunoreacting with huTFh and polypeptide analogs are described. Also contemplated are immunologic methods for detecting huTF heavy chain in body fluid, detecting thrombic events in vivo, isolating coagulation factor, and neutralizing VII/VIIa coagulation factor binding in vivo.

REFERENCES:
Proc. Natl. Acad. Sci vol. 83, pp. 299-302, Guha, et al. Jan. 1986, "Affinity purification . . . ".
J. Biol. Chem vol. 260 (20):10917-10920, Broze et al. 1985, "Purification of Human Brain T. F.".
Methods in Enzymology, vol. 92, pp. 17-26.
Carson, S. D. et al. 1985 Blood 66(1):152-6 Monoclonal Antibodies Against Bovine Tissue Factor . . . .
Carson, S. D. et al. 1987 Blood 70(2):490-3 An Inhibitory Monoclonal Antibody Against Human T. F.
Morrissey, J. H. et al. 1988. Thrombosis Res. 52:247-261. Monoclonal Antibody Analysis . . . .
Hancock, W. W., et al., J. Immunol. 136:2416 (1986).
Galvin, J. B. et al., J. Biol. Chem. 262:2199 (1986).

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