Hybridomas and resulting monoclonal antibodies directed against

Details Hybridomas and resulting monoclonal antibodies directed against Hybridomas and resulting monoclonal antibodies directed against

1989-02-17

1992-11-10

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

935103, 935106, 436513, 5303881, 5303882, 5303884, 42524027, C12N 1500, C12N 500, H01R 3108, A61K 3900

Patent

active

051622238

ABSTRACT:
A panel of monoclonal antibody (Mab) producing hybridomas directed against various antigens of Bordetella pertussis are disclosed herein. The hybridomas and the antigens that the resulting monoclonals are directed against include: (1) BPG10F8C3 and BPE8D8B1--lipooligosaccharide A (LOS A), serotype 1; (2) BPD5, BPE6, and BPF2--fimbriae, serotype 2; (3) BPE3, BPE8 and BPD8--69 kDa nonfimbrial protein, serotype 3; and (4) BPB7, BPC10, BPD4, BPD6, BPD9, and BPF5--fimbriae, serotype 6.

REFERENCES:
Abstracts and Program of the Sixth International Symposium on Pertussis, Mandark, Charles R. 1990, (ed) Dept. of Health & Human Services, Pub. No. (FDA) 90-1162, pp. 145-146, Leininger et al.
Pollack et al., "Specificity and Cross-Reactivity of Monoclonal Antibodies Reactive with the Core and Lipid A Regions of Bacterial Lipopolysaccharide," Journal of Infectious Diseases, vol. 159, No. 2, Feb. 1989, pp. 168-188.
Brennan et al., Inf & Immun. 56(12):3189. 1988.
Li et al., Inf & Immun. 56(3):699. 1988.
Li et al., Inf & Immun. 56(12):3184. 1988.
Gustafson et al., J. Clin. Microbiol. 26(19):2077. 1988.
Girard et al., Immunology 56:481. 1985.

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