Hybridomas and monoclonal antibodies to human IL-2

Details Hybridomas and monoclonal antibodies to human IL-2 Hybridomas and monoclonal antibodies to human IL-2

1986-03-10

1988-09-20

Tarcza, John E.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 68, 435948, 436548, 530387, C12N 500, A61K 39395, G01N 3354, C12R 191

Patent

active

047725729

ABSTRACT:
Certain hybridomas preparing monoclonal antibodies to human interleukin-2 (IL-2) which do not cross react with rator mouse IL-2 are disclosed. The secreted monoclonal antibody can be used in immunoassays for human IL-2.

REFERENCES:
patent: 4473493 (1984-09-01), Gillis
patent: 4636463 (1987-01-01), Altman et al.
patent: 4690893 (1987-09-01), Mosmann
Gillis et al., "Generation of a B Cell Hybridoma Whose Antibody Product Inhibits Interleukin 2 Activity", Journal of Immunology 126(5), pp. 1978-84 (1981).
Stadler et al., "Human Interleukin-2: Biological Studies Using Purified IL-2 and Monoclonal Anti-IL-2 Antiobodies", Lymphokines 6, pp. 117-35 (1982).
Stadler et al., "Monoclonal Antibody Against Human Interleukin 2 (IL 2), Journal of Immunology 128(4), pp. 1620-4 (4-1982).

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