Hybridomas and monoclonal antibodies therefrom reactive toward a

Details Hybridomas and monoclonal antibodies therefrom reactive toward a Hybridomas and monoclonal antibodies therefrom reactive toward a

1989-11-03

1993-08-24

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

5303881, 5303871, 436548, A61K 3514

Patent

active

052388247

ABSTRACT:
A hybridoma cell line produces an antibody with reactivity directed specifically to immunodominant antigens from the catfish pathogen Edwardsiella ictaluri, the antigens having molecular weights of about 14,000, 39,000, 48,000, 60,000, 66,000, 83,000, and 93,000 daltons. This antibody is specific for proteins of E. ictaluri but not for other catfish pathogens. It is therefore useful for the positive identification of E. ictaluri from body fluids and tissue of catfish and for identification and purification of the reactive immunodominant antigens.

REFERENCES:
J. A. Plumb et al., "An Assessment of the Antigenic Homogeneity of Edwardsiella ictaluri Using Monoclonal Anbibody," J. Fish Dis. 11:499-509 (1988).
P. Waterstrat et al., "Use of an Indirect Enzyme-Linked Immunosorbent Assay (ELISA) in the Detection of Channel Catfish, Ictalurus punctatus (Raninesque), Antibodies to Edwardsiella ictaluri," J. Fish Dis. 12:87-94 (1989).
Craig J. Lobb et al., "Immunoglobulin Light Chain Classes in a Teleost Fish," J. Immunol. 132(4):1917-1923 (Apr. 1984).
N. W. Miller et al., "Phylogeny of Lymphocyte Heterogeneity: Identification and Separation of Functionally Distinct Subpopulations of Channel Catfish Lymphocytes with Monoclonal Antibodies," Dev. Comp. Immunol. 11:739-747 (1987).
A. J. Ainsworth et al., "Use of Monoclonal Antibodies in the Indirect Fluorescent Antibody Technique (IFA) for the Diagnosis of Edwardsiella ictaluri," J. Fish Dis. 9:439-444 (1986).
Nigel Palmer letter to Phillip H. Klesius dated May 13, 1991, disclosing mailing date to subscribers of J. Fish Dis. 11(6) (Nov. 1988).
Ainsworth et al., Biol. Abstr. 83(6) 1987, 55627, "Use of Monoclonal Antibodies in the Indirect Fluorescent Antibody Technique for the Diagnosis of Edwardsiella ictaluri".

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