Hybridomas and monoclonal antibodies that speifically bind to GP

Details Hybridomas and monoclonal antibodies that speifically bind to GP Hybridomas and monoclonal antibodies that speifically bind to GP

1993-10-25

1996-01-23

Hutzell, Paula K.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241431, 43524027, 4351722, 435 7021, 435 72, 53038822, 5303887, A61K 39395, C07K 1628, C12N 520

Patent

active

054863619

ABSTRACT:
Monoclonal antibodies which specifically bind to glycoprotein Ib are described. These antibodies completely inhibit the binding of thrombin to platelets, thereby totally inhibiting the activation of platelets by thrombin. The antibodies also completely inhibit platelet aggregation and also significantly inhibit adhesion of platelets to a subendothelial arterial surface in an ex vivo model system.

REFERENCES:
Harris et al. Tibtech 11:42-44, 1993.
Tanaka et al. Microbiol. Immunol. vol. 29 (10):959-972, 1985.
Harlow et al. "Antibodies A Laboratory Manual" Cold Spring Harbor Laboratory 1988, p. 287.
Yamamoto et al., Thrombosis Research, vol. 39, No. 6, pp. 751-759 (1985).
Yamamoto et al. Thrombosis and Haemostasis, vol. 55 (2), pp. 162-167 (1986).
Katagiri et al., Thrombosis and Haemostasis, vol. 63 (1), pp. 122-126 (1990).
Yamamoto et al., Blood, vol. 77, No. 8, pp. 1740-1748 (1991).
Ruan et al., "A Monoclonal Antibody to Human Platelet GPIb Inhibited Both Ristocetin-and Collagen-Induced Aggregation", INSERM Symposium, No. 27, pp. 59-68 (1986).
DeMarco et al., The Journal of Biological Chemistry, vol. 266, No. 35, pp. 23776-23783 (1991).
Mazurov et al., Thrombosis Research, vol. 62, No. 6, pp. 673-684 (1991).

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