Hybridoma-producing NSO myeloma cell line

Details Hybridoma-producing NSO myeloma cell line Hybridoma-producing NSO myeloma cell line

1994-08-23

1996-10-15

Feisee, Lila

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

435 697, 435 7021, 4351721, 4351722, 4351723, 4352402, 43524021, 43524027, 43524026, 5303881, 5303873, C12P 2108, C12N 1502, C12N 512, C07K 1600

Patent

active

055653375

ABSTRACT:
This invention relates to an NSO myeloma cell line which has increased fusion frequency, and to a method of producing said cell line. The NSO cell line of the invention, when fused with B cells, produces monoclonal antibody-secreting hybridoma which has increased resistance to death. In addition, the monoclonal antibodies secreted by said hybridomas have increased affinity for foreign antigens and for autoantigens.

REFERENCES:
Morrison, S. L., Science, 229:1202-1207, 20 Sep. 1985.
Sinbovics, J. G., Acta Microbiol Hung (Hungary), 38(3-4):321-34, 1991.

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