Hybridoma cell lines and monoclonal antibodies to clostridum dif

Details Hybridoma cell lines and monoclonal antibodies to clostridum dif Hybridoma cell lines and monoclonal antibodies to clostridum dif

1986-05-30

1991-12-10

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

530387, 530388, 435 7021, 4351722, 436548, C12N 520, C12N 1502, C07K 1528, C12P 2108

Patent

active

050717596

ABSTRACT:
Monoclonal antibodies produced by a family of murine hybrid cell lines are cross-reactive with both toxin A and toxin B of Clostridium difficile. The monoclonal antibodies are useful in an immunoassay for toxin A and toxin B of C. difficile, a casual agent of antibiotic-associated pseudomembranous colitis in humans and animals.

REFERENCES:
Lyerly, D. M. et al. (II), "Characterization of Toxins A and B of Clostrim difficile with Monoclonal Antibodies", Infect. Immun. 54(1): 70-76, Oct. 1986.
Lyerly, D. M., et al. (III), "Monoclonal and Specific Polyclonal Antibodies for Immunoassay of Clostridium difficle Toxin A", J. Clin. Microbiol. 21(1): 12-14, Jan. 1985.
Lyerly, D. M. et al. (I), "Monoclonal Antibodies Against Toxins A and B of Clostridium-Difficile", Abstr. Annu. Meet. Am. Soc. Microbiol., Mar. 23-28, 1986, B61, p. 34.
Rolfe, R. et al., "Monoclonal Antibodies Against Clostridium-Difficile Toxins A and B", Abstr. Annu. Meet. Am. Soc. Microbiol., Mar. 23-28, 1986, B62, p. 34.
Rothman, S. W. et al., "Differential Cytotoxic Effects of Toxins A and B Isolated from Clostridium difficile", Infect. Immun. 46(2): 324-331, Nov. 1984.

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