Hybridoma cell lines and monoclonal antibodies recognizing...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S388200, C530S388230, C530S388240, C435S326000

Reexamination Certificate

active

07411049

ABSTRACT:
Monoclonal antibodies to Prox1 of vertebrates (pfam05044.5; NM_002763.3) and two continuous cell lines for their production are disclosed. These antibodies are particularly useful in immunoassays to detect the presence of Prox1 protein in vertebrate tissues and cells.

REFERENCES:
patent: 5055405 (1991-10-01), Wang et al.
patent: 6818215 (2004-11-01), Smith et al.
J.T. Wigle et al., “Prox1function is crucial for mouse lens-fibre elongation,”Nature Genetics, (Mar. 1999), pp. 318-322, vol. 21.
M.K. Duncan et al., “Prox1 is differentially localized during lens development,”Mechanisms of Development, (2002), pp. 195-198, vol. 112.
Kohler, G. and Milstein, C., “Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity,” Nature, Aug. 7, 1975, vol. 256, pp. 495-497.
Hong, Young-Kwon et al., “Prox1 is a Master Control Gene in the Program Specifying Lymphatic Endothelial Cell Fate,” Developmenal Dynamics, 2002, vol. 225, pp. 351-357.
Hassan, Bassem et al., “Prospero is a Panneural Transcription Factor that Modulates Homeodomain Protein Activity,” Proc. Natl. Acad. Sci. USA, Sep. 1997, vol. 94, pp. 10991-10996.
Dyer, Michael A. et al, “Prox1 Function Controls Progenitor Cell Proliferation and Horizontal Cell Genesis in the Mammalian Retna,” Nature Genetics, May 2003, vol. 34, pp. 53-58.
Dudas, J. et al., “The Homeobox Transcription Factor Prox1 is Highly Conserved in Embryonic Hepatoblasts and in Adult and Transformed Hepatocytes, But is Absent from Bile Duct Epithelium,” Anat. Embryol, 2004, vol. 208, pp. 359-366.
De Coupade, Catherine et al., “Novel Human-Derived Cell-Penetrating Peptides for Specific Subcellular Delivery of Therapeutic Biomolecules,” Biochem. Journal, 2005, vol. 390, pp. 407-418.
Cui, Wenwu et al., “Mafs, Prox1, and Pax6 Can Regulate Chicken βB1-Crystallin Gene Expression,” Journal of Biological Chemistry, Mar. 2004, vol. 279, No. 12, pp. 11088-11095.
Cook, Tiffany et al., “Distinction Between Color Photoreceptor Cell Fates is Controlled by Prospero in Drosphila,” Developmental Cell, Jun. 2003, vol. 4, pp. 853-864.
Chen, Xiaoren et al., “Production of Monoclonal Antibodies Against Prox1,” Hybridoma, 2006, vol. 25, No. 1, pp. 27-33.
Burke, Zoe and Oliver, Guillermo, “Prox1 is an Early Specific Marker for Developing Liver and Pancreas in the Mammalian Forgut Endoderm,” Mechanisms of Development, 2002, vol. 118, pp. 147-155.
Burglin, T.R., “ACaenorhabditis elegansProspero Homologue Defines a novel Domain,” Trends in Biochem. Science, Feb. 1994, vol. 19, pp. 70-71.
Bi, Xiaolin et al., “The Carboxy Terminus of Prospero Regulates Its Subcellular Localization,” Molecular and Cellular Biology, Feb. 2003, vol. 23, No. 3, pp. 1014-1024.
Sosa-Pineda, Beatriz et al., “Hepatocyte Migration During Liver Development Requires Prox1,” Nature Genetics, Jul. 2000, vol. 25, pp. 254-255.
Ryter, Jodi M. et al., “Structure of the DNA Binding Region of Prospero Reveals a Novel Homeo-Prospero Domain,” Structure, Nov. 2002, vol. 10, pp. 1541-1549.
Reis-Filho, Jorge Sergio and Schmitt, Fernando C., “Lymphangiogenesis in Tumors: What Do We Know?” Microscopy Research and Technique, 2003, vol. 60, pp. 171-180.
Reed, Nathan A. et al, “An Immunohistochemical Method for the Detection of Proteins in the Vertebrate Lens,” Journal of Immunological Methods, 2001, vol. 253, pp. 243-252.
Qin, Jun et al., “Prospero-Related Homeobox (Prox1) is a Corepressor of Human Liver Receptor Homolog-1 and Suppresses the Transcription of the Cholesterol 7-α-Hydroxylase Gene,” Molecular Endocrinology, 2004, vol. 18, No. 10, pp. 2424-2439.
Petrova, Tatiana V. et al., “Lymphatic Endothelial Reprogramming of Vascular Endothelial Cells by the Prox-1 Homeobox Transcription Factor,” The EMBO Journal, 2002, vol. 21, No. 17, pp. 4593-4599.
Oliver, Guillermo et al., “Prox 1, a Prospero-Related Homeobox Gene Expressed During Mouse Development,” Mechanisms of Development, 1993, vol. 44, pp. 3-16.
Nelson, P.N. et al., “Monoclonal Antibodies,” J. Clinical. Pathol: Mol. Path, 2000, vol. 53, pp. 111-117.
Lengler, Johannes et al., “Antagonistic Action of Six3 and Prox1 at the γ-Crystallin Promoter,” Nucleic Acids Research, 2001, vol. 29, No. 2, pp. 515-526.
Van Der Auwera, Ilse et al., “Increased Angiogenesis and Lymphangiogenesis in Inflammatory Versus Noninflammatory Breast Cancer by Real-Time Reverse Transcriptase-PCR Gene Expression Quantification,” Clinical Cancer Research, Dec. 2004, vol. 10, pp. 7965-7971.
Tomarev, Stanislav I et al., “Characterization of the Mouse Prox1 Gene,” Biochemical and Biophysical Research Communications, 1998, vol. 248, pp. 684-689.
Tomarev, Stanislav I et al., “Chicken Homeobox Gene Prox 1 Related to Drosophila Prospero is Expressed in the Developing Lens and Retina,” Developmental Dynamics, 1996, vol. 206, pp. 354-367.
Chatenoud, Lucienne, “Monoclonal Antibody-Based Strategies in Autoimmunity and Transplantation,” Methods in Molecular Medicine, 2005, vol. 109, pp. 297-328.
Doe, Chris Q. et al., “The Prospero Gene Specifies Cell Fates in the Drosophila Central Nervous Systems,” Cell, May 1991, vol. 65, pp. 451-464.
Al-Rawi, M.A.A. et al., “Lymphangiogenesis and Its Role in Cancer,” Histology and Histophathology, 2005, vol. 20, No. 1, pp. 283-298.
Kellogg, Douglas R. and Moazed, Danesh, “Protein- and Immunoaffinity Purification of Multiprotein Complexes,” Methods in Enzymol, 2002, vol. 351, pp. 172-183.
Zinovieva, Rina D. et al., “Structure and Chromosomal Localization of the Human Homeobox Gene Prox 1,” Genomics, 1996, vol. 35, pp. 517-522.
Yousef, Mmohammad S. and Matthews, Brian W., “Structural Basis of Prospero-DNA Interaction: Implications for Transcription Regulation in Developing Cells,” Structure, Apr. 2005, vol. 13, pp. 601-607.
Yoo, Ester M. et al., “Myeloma Expression Systems,” Journal of Immunological Methods, 2002, vol. 261, pp. 1-20.
Wilting, Jorg et al., “The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues,” The FASEB Journal, 2002, vol. 16, pp. 1271-1273.
Wigle, Jeffrey T. et al., “An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype,” The EMBO Journal, 2002, vol. 21, No. 7, pp. 1505-1513.
Wigle, Jeffrey T. and Oliver, Guillermo, “Prox 1 function is required for the development of the murine lymphatic system,” Cell, Sep. 1999, vol. 98, pp. 769-778.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Hybridoma cell lines and monoclonal antibodies recognizing... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hybridoma cell lines and monoclonal antibodies recognizing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hybridoma cell lines and monoclonal antibodies recognizing... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4014516

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.