Hybridoma antibody which binds IL-2 receptor

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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530808, 530809, 435 68, 4351722, 4352401, 43524026, 43524027, 935 89, 935 95, 935106, 424 858, C07K 1500, C12N 500, C12N 1500

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active

048451983

ABSTRACT:
A monoclonal antibody which specifically binds to the human IL-2 receptor, and a hybridoma which produces the antibody, are disclosed.

REFERENCES:
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Malek et al., "Identification and Initial Characterization of a Rat Monoclonal Antibody Reactive with the Murine Interleukin 2 Receptor-Ligand Complex," Proc. Natl. Acad. Sci. USA 80:5694 (1983).
Depper et al., "Blockade of the Interleukin-2 Receptor By Anti-Tac Antibody: Inhibition of Human Lymphocyte Activation," J. Immunol. 131:690 (1983).
Robb et al., "Direct Demonstration of the Identity of T Cell Growth Factor Binding Protein and the Tac Antigen," J. Exp. Med. 158:1332 (1983).
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Hemler et al., "A 55,000 M.sub.r Surface Antigen on Activated Human T Lymphocytes Defined by a Monoclonal Antibody," Human Immunology 8:153 (1983).

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