Hybridoma and monoclonal antibody MLS102 which recognizes a NeuA

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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5303875, 5303888, 435 7021, 4351722, C12N 520, C12N 1502, C07K 1528, C12P 2108

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active

051943859

ABSTRACT:
The present invention relates to a monoclonal antibody MLS 102 recognizing human intestinal cancer cells, especially their sugar chain of glycoprotein, and more specifically NeuAc .alpha.2.fwdarw.6GalNAc. The invention also relates to a hybridoma producing the monoclonal antibody which is prepared by fusing splenic cells of a mouse immunized by human intestinal cancer cells with myeloma cells.

REFERENCES:
Johnson, V. G. et al. "Analysis of a Human Tumor-Associated Glycoprotein (TAG-72) Identified by Monoclonal Antibody B72.3", Cancer Research 46:850-857, Feb. 1986.
Colcher, D. et al. "A Spectrum of Monoclonal Antibodies Reactive with Human Mammary Tumor Cells," Proc. Nat'l. Acad. Sci. 78(5):3199-3203, May 1981.
Kurosaka, A. et al. "Mucin-Carbohydrate Directed Monoclonal Antibody," FEBS Letters 215(1):137-139, May 1987.
Nudelman, E. et al. "Novel Fucolipids of Human Adenocarcinoma. Disialosyl Le.sup.a Antigen (III.sup.4 Fuc III.sup.6 NeuAcIV.sup.3 NeuAcLc.sub.4) of Human Colonic Adenocarcinoma and the Monoclonal Antibody (FH7) Defining This Structure," J. Biol. Chem. 261(12):5487-5495, Apr. 25, 1986.
Gottschalk, A. et al. "Submaxillary Gland Glycoproteins," In: Glycoproteins, Gottschalk, A. (ed.), Elsevier, Amsterdam, New York, 1972, pp. 810-829.
Kannagi et al. in Weir et al. Eds. "Handbook of Exptl. Immunol." vol. 4, Blackwell Sci Publ., May 30, 1986.
Giraldo et al, "From Oncogenes to Tumor Antigens" Elsevier Sci. Publ. 1985.
Kurosaka et al., J. Biol. Chem 263:8724-8776, 1988.
The Journal of Biological Chemistry, Nakada et al., vol. 266, No. 19, pp. 12402-12405, 1991.

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