Hybridization of polynucleotides conjugated with chromophores an

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 56, 435800, 536 243, 422 8201, 422 8202, 422 8208, C12Q 168, C07H 2104, G01N 2700, G01N 3700

Patent

active

058494898

ABSTRACT:
The present invention contemplates chromophore-containing polynucleotides having at least two donor chromophores operatively linked to the polynucleotide by linker arms, such that the chromophores are positioned by linkage along the length of the polynucleotide at a donor--donor transfer distance, and at least one fluorescing acceptor chromophore operatively linked to the polynucleotide by a linker arm, such that the fluorescing acceptor chromophore is positioned by linkage at a donor-acceptor transfer distance from at least one of the donor chromophores, to form a photonic structure for collecting photonic energy and transferring the energy to an acceptor chromophore, and methods using the photonic structures.

REFERENCES:
patent: 4822746 (1989-04-01), Walt
patent: 4868103 (1989-09-01), Stavrianopoulos et al.
patent: 4996143 (1991-02-01), Heller
patent: 5237515 (1993-08-01), Herron et al.
patent: 5565322 (1996-10-01), Heller
Kornberg, Arthur, "DNA Synthesis", 1974.
Cardullo et al., Proc. Natl. Acad. Sci. USA, 85:8790-8794 (1988).
Garner et al., Anal. Chem., 62:2193-2198 (1990).
Haddon et al., Proc. Natl. Acad. Sci. USA, 92: 1874-1878 (1985).
Heller et al., in "Rapid Detection and Infection of Infectious Diseases", Kingsbury et al., eds, Acad Pr, NY, pp. 245-256 (1985).
Hopfield et al., Science, 241:817-820 (1988).
Keller et al., in "DNA Probes", pp. 104-108,Stockton Press, N.Y. (1989).
McAlear et al., in "Molecular Electronic Devices II", pp. 623-633, Carter, et al., Marcel Dekker, Inc., N.Y. (1987).
Morrison et al., Anal. Biochem., 183-231-244 (1989).
Robinson et al., Protein Eng., 1:295-300 (1987).
Glazer, et al., Emerging Techniques: Physofluor probes, Trends in Biochemical Sciences, vol. 9, No. 10, pp. 423 (1984).
Tyagi et al., Molecular Beacons: Probes that Fluoresce upon Hybridization, Nature Biotechnology, vol. 14 (Mar., 1996).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Hybridization of polynucleotides conjugated with chromophores an does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hybridization of polynucleotides conjugated with chromophores an, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hybridization of polynucleotides conjugated with chromophores an will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1456500

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.