Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-07-24
1998-09-01
Jones, W. Gary
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 5, 435 4, 435 912, 536 243, 536 2433, 536 2436, C12Q 168, C12Q 170, C12P 1934, C07H 2104
Patent
active
058009949
ABSTRACT:
A new method has been developed for conducting a gene probe assay. The preferred technique involves (1) using a gene amplification technique (e.g., PCR) to multiply the gene sequence of interest and (2) using a hybridization--ligation detection methodology, wherein the sequences of probes hybridized to the target sequence allow for separation and detection (e.g., probes might contain a combination of magnetic particles and acridinium esters) to determine if a specific sequence is present.
REFERENCES:
patent: 4486539 (1984-12-01), Ranki
patent: 4563419 (1986-01-01), Ranki
patent: 4883750 (1989-11-01), Whitely et al.
patent: 4925785 (1990-05-01), Wang et al.
patent: 4988617 (1991-01-01), Landegren
patent: 5241070 (1993-08-01), Law et al.
patent: 5242794 (1993-09-01), Whiteley
patent: 5312910 (1994-05-01), Kishore et al.
patent: 5407798 (1995-04-01), Martinelli et al.
Barnay, F., 88 Proc Natl. Acad. Sci. USA 189, 1991.
Innis, et al, PCR Protocols, Academic Press, 1990.
Kerem, B., et al, 87 Proc. Natl. Acad. Sci. USA 8447, 1990.
Landegren, et al, 241 Science 1077, 1988.
Landegren, 15 BioEssays 761, 1993.
Plaha, et al, 14 BioTechniques 566, 1993.
Riordan, J.R., et al, 245 Science 1066, 1989.
Saiki, R.K., et al, 230 Science 1350, 1985.
Saiki, R.K., et al, 239 Science 487, 1988.
Wu, D.Y., et al, 4 Genomics 560, 1989.
Zielenski, et al, 10 Genomics 214, 1991.
Klausner, A. et al, Biotechnology, p. 471, Aug., 1983.
Maniatis, T. et al, Molecular Cloning. A Laboratory Manual. Cold Spring Harbor publication, NY., p. 146, 1982.
Meinkoth, J. et al, 138 Analytical Biochemistry 267, 1984.
Nickerson, D. et al, 87 Proc. Natl. Acad. Sci. USA 8923, 1990.
Maniatis in Molecular Cloning a Laboratory Manual, Cold Spring Harbor, 1982, pp. 140-144, 202, 388, 447.
Tchurikiv et al. Febs Lett 297: 233-36 (Abstract Provided), 1992.
Arruda John C.
Martinelli Richard A.
Blackburn Robert P.
Chiron Diagnostics Corporation
Jones W. Gary
Morgenstern Arthur S.
Rees Dianne
LandOfFree
Hybridization-ligation assays for the detection of specific nucl does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hybridization-ligation assays for the detection of specific nucl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hybridization-ligation assays for the detection of specific nucl will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-268959