Hybrid with interferon-alpha and an immunoglobulin Fc linked thr

Details Hybrid with interferon-alpha and an immunoglobulin Fc linked thr Hybrid with interferon-alpha and an immunoglobulin Fc linked thr

1996-09-25

1998-03-03

Feisee, Lila

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

4241851, 4241921, 435 697, 5303873, 530351, 536 234, A61K 39395, A61K 3900, C07K 1600, C07K 100

Patent

active

057231257

ABSTRACT:
Disclosed is a hybrid recombinant protein consisting of human interferon, preferably interferon-.alpha. (IFN.alpha.), and human immunoglobulin Fc fragment, preferably .gamma.4 chain, joined by a peptide linker comprising the sequence Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser (SEQ ID NO:1).

REFERENCES:
patent: 5349053 (1994-09-01), Landolfi
Huston, JS et al Methods in Enzymology vol. 203 pp. 46-88, 1991.

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