Hybrid slab-microchannel gel electrophoresis system

Details Hybrid slab-microchannel gel electrophoresis system Hybrid slab-microchannel gel electrophoresis system

1996-04-05

1998-05-05

Gorgos, Kathryn L.

Chemistry: electrical and wave energy

Apparatus

Electrophoretic or electro-osmotic apparatus

204456, 204466, 204616, G01N 2726, G01N 27447

Patent

active

057469016

ABSTRACT:
A hybrid slab-microchannel gel electrophoresis system. The hybrid system permits the fabrication of isolated microchannels for biomolecule separations without imposing the constraint of a totally sealed system. The hybrid system is reusable and ultimately much simpler and less costly to manufacture than a closed channel plate system. The hybrid system incorporates a microslab portion of the separation medium above the microchannels, thus at least substantially reducing the possibility of non-uniform field distribution and breakdown due to uncontrollable leakage. A microslab of the sieving matrix is built into the system by using plastic spacer materials and is used to uniformly couple the top plate with the bottom microchannel plate.

REFERENCES:
patent: 4417967 (1983-11-01), Ledley
patent: 4762743 (1988-08-01), von Alren et al.
patent: 5047135 (1991-09-01), Nieman
patent: 5071531 (1991-12-01), Soane
patent: 5192412 (1993-03-01), Kambara et al.
UCRL-119660, J.W. Balch et al., "Advanced Microinstrumentation for Rapid DNA Sequencing and Large DNA Fragment Separation", 1995.

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