Hybrid RNA virus

Details Hybrid RNA virus Hybrid RNA virus

1995-06-07

1997-05-06

Fox, David T.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 691, 435 701, 4352351, 4353201, 536 2372, C12N 1540, C12N 1582, C12N 1583

Patent

active

056270607

ABSTRACT:
A recombinant RNA virus is provided allowing encapsidation of genetically engineered viral sequences in heterologous, preferably rod-shaped coat, protein capsids. Since icosahedral viruses are limited in the amount of RNA they can carry, and rod-shaped viruses are expansible, this invention allows the size of recombinant virus RNA components to be increased (or decreased). Methods of making and using such recombinant viruses are also provided, specifically with respect to the transfection of plants to bring about genotypic and phenotypic changes.

REFERENCES:
Sleat et al. (1986) Virology 155: 299-308.
Ahlquist et al. (1984) J. Mol. Biol. 172:369-383.
Meshi et al. (1981) Mol. Gen. Genet. 184:20-25.
Stanway et al. (1986) J. Virol. 57:1187.
Semler et al. (1986) Proc. Natl. Acad. Sci. USA 83:1777.
Takamatsu et al. (1987) EMBO J. 6:307-311.
French et al. (1986) Science 231:1294-1297.

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