Hybrid RNA virus

Details Hybrid RNA virus Hybrid RNA virus

1995-05-22

1997-02-11

Fox, David T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

526 241, 435 691, 4351723, 4352351, 4353201, C12N 1533, C12N 1540, C12N 1582, C12N 1583

Patent

active

056022425

ABSTRACT:
A recombinant RNA virus is provided allowing encapsidation of genetically engineered viral sequences in heterologous, preferably rod-shaped coat, protein capsids. Since icosahedral viruses are limited in the amount of RNA they can carry, and rod-shaped viruses are expansible, this invention allows the size of recombinant virus RNA components to be increased (or decreased). Methods of making and using such recombinant viruses are also provided, specifically with respect to the transfection of plants to bring about genotypic and phenotypic changes.

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Luria et al. 1978. General Virology, Third edition, pp. 58-60.
Agol et al. Virology 136:41-55 (1984).
Stanway et al. 1986. J. Virol. 57:1187-1190.
Semler et al. 1986. Proc. Natl. Acad. Sci. USA 83:1777-1781.
Habili et al. 1974. Virology 61(2): 443-449.
Sleat et al. (1986) virology 155:299-308.
Sacher et al. (1988) Virology 167:15-24.
Ahlquist et al. (1984) J. Mol. Biol. 172:369-383.
Meshi et al. (1981) Mol. Gen. Genet. 184:20-25.
Takamatsu et al. (1987) EMBO J. 6:307-311.
French et al. (1986) Science 231:1294-1297.

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