Hybrid reagents capable of selectively releasing molecules into

Details Hybrid reagents capable of selectively releasing molecules into Hybrid reagents capable of selectively releasing molecules into

1992-12-28

1996-03-26

Feisee, Lila

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

4241431, 4241501, 4241781, 5303873, 5303882, 5303884, 5303911, A61K 39395, A61K 3940, C12P 2108, C07K 1646

Patent

active

055018548

ABSTRACT:
Hybrid reagents comprising a first portion having an affinity for a cellular target and a second portion having an affinity for a bioactive molecule are described, said hybrid reagents being capable of selectively releasing the bioactive molecule in response to a change in pH. The hybrid reagents of the present invention can be used diagnostically or therapeutically.

REFERENCES:
patent: 4470925 (1984-09-01), Auditore-Hargreaves
patent: 4474893 (1984-10-01), Reading
patent: 4479895 (1984-10-01), Auditore-Hargreaves
patent: 4676980 (1987-06-01), Segal et al.
patent: 4698420 (1987-10-01), Urnovitz
Waldman Science vol. 252 1657 1991.
Hird Genes and Cancer ; Corvey and Sikola ed. 1990.
Harris TibTech vol. 11, p. 42 1993.
Brennan et al (1985) Science 229:81-83.
Glennie et al (1981) J. Immunol 139(7):2367-2375.
Griffin et al (1987) Cancer Res. 47:4266-4270.
Alkan et al (1988) J. Interferon Res. 8(1):25-33 as represented by CA 108(3):110616m.
Laky et al (1987) Immunol. Lett. 14(2):127-32 See CA106 (23):188549v.
Moa et al (1988) Immunol. Lett 17(2):177-82 See CA108(13):106081v.
Schlossman et al (1988) GP 294703 Published 14 Dec. 1989 CA111CA):76400m.
Tsukada et al (1989) Cancer Biochem. Biophys. 10 (3):247-56.
Raso, V. and T. Griffin, Cancer Res., 41:2073-2078 (1981).
Raso, V., Immunological Rev., 62:93-117 (1982).
Raso & Basala, In: Receptor-Mediated Targeting of Drugs (1984).
Neville, et al., Journal Biol. Chem. 264(25):14653-14661 (1989) Medlini Abstract.
Paik et al., The Journal of Nuclear Medicine 30(10):1693-1701 (1989).

Affiliated with

Also associated with

Rating

Hybrid reagents capable of selectively releasing molecules into does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hybrid reagents capable of selectively releasing molecules into , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hybrid reagents capable of selectively releasing molecules into will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-914080