Hybrid proteins with modified activity

Details Hybrid proteins with modified activity Hybrid proteins with modified activity

1999-06-03

2000-12-05

Priebe, Scott D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 235, 514 44, 514 12, C07H 2102, C07H 2104, A01N 4304

Patent

active

061568880

ABSTRACT:
Hybrid proteins which affect blood coagulation comprise a region from a donor anticoagulant or antithrombotic protein, and the resulting hybrid protein has a modified biological activity. Information concerning the hybrid proteins implicates DNA sequences encoding the proteins and hosts, including transgenic animals, that possess these DNA sequences; antibodies directed against hybrid proteins; methods of modifying the properties of proteins; and treatment methods employing hybrid proteins.

REFERENCES:
patent: 4868112 (1989-09-01), Toole
patent: 5286487 (1994-02-01), Vallee et al.
patent: 5358932 (1994-10-01), Foster et al.
patent: 5364771 (1994-11-01), Lollar et al.
patent: 5910481 (1999-06-01), Voorberg
patent: 6051418 (2000-04-01), Voorberg
Verma et al. Nature 389:239-242, Sep. 1997.
Anderson Nature 392:25-30, Apr. 1998.
Kay et al. Proceedings of the National Academy of Science USA 96:9973-9975, Sep. 1997.
Aledort, Sem. Hematol. 30(2): 7-9 (1993).
Bode et al., EMBO J. 8(11): 3467-75 (1989).
Brackman et al., Lancet 2: 933 (1977).
Chibber et al., Biochemistry 24: 3429-34 (1985).
Coughlin et al., J. Clin. Invest. 89:351-55 (1992).
Culver et al., Science 256: 1550-52 (1992).
Davie et al., Science 145: 1310-12 (1964).
Davie et al., Biochem. 30(43): 10363-70 (1991).
Eaton et al., Biochemistry 25(26): 8343-47 (1986).
Eaton et al., Biochem. 25: 505-12 (1986).
Esmon, Thromb. Haemost. 70(1): 29-35 (1993).
Fay et al. Thromb. Haemost. 70: 63-67 (1993).
Foss et al., Blood 84(6): 1765-74 (1994).
Gailani et al., Science 253: 909-12 (1991).
Graham et al. Virology 52: 456-67 (1973).
Grutter et al., EMBO J. 9(8): 2361-65 (1990).
Hortin et al., Biochem. Biophys. Res. Commun. 169(2): 437-442 (1990).
Huber et al., Biochem. 28(23): 8951-66 (1989).
Jackson et al., Ann. Rev. Biochem. 49: 765 (1980).
Jesty, Haemostasis 21: 208-18 (1991).
Johnson et al., "Peptide Turn Mimetics" in Biotechnology and Pharmacy.
Kane et al. Blood 71(3): 539-55 (1988).
Kreitman et al., Biochemistry 33: 11637-44 (1994).
Lenting et al., J. Biol. Chem. 269: 7150-55 (1994).
Leyte et al., J. Biol. Chem. 266(2): 740-46 (1991).
Leyte et al., J. Biochem. 263: 187-94 (1989).
Liu et al., J. Biol. Chem. 266(26): 16977-80 (1991).
Lollar et al., J. Biol. Chem. 263(21): 10451-55 (1988).
Lollar et al. Biochemistry 28: 666-74 (1989).
MacFarlane, Nature 202: 498-99 (1964).
Mann et al., Blood 76(1): 1-16 (1990).
Mathews et al., Biochemistry 33: 3266-79 (1994).
Mertens et al., Brit. J. Haematol. 85: 1-10 (1993).
Mertens et al., J. Biochem. 223: 599-605 (1984).
Michnick et al., J. Biol. Chem. 269(31): 20095-102 (1994).
Mikkelsen et al., Biochemistry 30: 1533-37 (1991).
Neuenschwander et al., Analyt. Biochem. 184: 347-52 (1990).
Pittman et al., Biochemistry 31(13): 3315-25 (1992).
Rosenberg et al., Human Gene Therapy 3: 57-75 (1992).
Rydel et al., Science 249: 277-80 (1990).
Saragovi et al., Science 253: 792-95 (1991).
Sarver et al., DNA 6(6):553-64 (1987).
Skrzypczak-Jankun et al., J. Mol. Biol. 206: 755-57 (1989).
Stubbs et al., Thromb. Res. 69: 1-58 (1993).
te Riele et al., Nature 348: 649-51 (1990).
Toole et al., Proc. Nat'l Acad. Sci. USA 83: 5939-42 (1986).
Tsiang et al., Biochemistry 29: 10602-12 (1990).
Van Deerlin et al., J. Biol. Chem. 266(30): 20223-31 (1991).
Vu et al., Nature 353: 674-77 (1991).
Yelton et al., Ann. Rev. Biochem. 50: 657-680 (1981).
Donath et al., Activation and Limited Proteolysis of Human Blood Coagulation Factor VIII, pp. 33-48 (1995).
Mertens et al., British Journal of Haematology 85: 133-142 (1993).
Voorberg et al., Journal of Biological Chemistry 271(35): 20985-20988 (1996).

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