Hybrid polypeptides comprising somatocrinine and alpha.sub.1 -an

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide

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435 69, 435 70, 435 91, 4351723, 435320, 43525233, 435849, 935 47, 935 13, 935 29, 935 60, 935 73, 530313, 530324, 530343, 530350, 530380, 530402, 530407, C12P 2100, C12P 2102, A61K 3743, C07K 100, C12N 1500

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048289884

ABSTRACT:
A fusion between DNA sequences coding for hAT and hGRF via a synthetic adaptor coding for an in vitro cleavable amino acid sequence is used to express hGRF at high levels in E. coli.

REFERENCES:
patent: 4546082 (1985-10-01), Kurjan et al.
patent: 4617149 (1986-10-01), DiMarchi et al.
patent: 4689318 (1987-08-01), Kaiser et al.
Cravador et al, Biochimie, vol. 67 (7-8), pp. 829-834 Jul. 1985, "Total DNA Synthesis and Cloning in Escherichia coli of a Gene Coding for the Human Growth Hormone Releasing Factor".
Guillemin et al., Science, 218:585 (1982).

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