Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Reexamination Certificate
2006-12-12
2006-12-12
Nashed, Nashaat T. (Department: 1656)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
C536S023200
Reexamination Certificate
active
07148045
ABSTRACT:
A polyketide synthase (“PKS”) of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. The first extension module receives an acyl starter unit from the loading domain and each extension module adds a further ketide unit which may undergo processing (e.g. reduction). We have found that the Ksq domain possessed by some PKS's has decarboxylating activity, e.g. generating (substituted) acyl from (substituted) malonyl. The CLF domain of type II PKS's has similar activity. By inserting loading modules including such domains into PKS's not normally possessing them it is possible to control the starter units used.
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Cortes Jesus
Leadlay Peter Francis
McArthur Hamish Alastair Irvine
Staunton James
Biotica Technology Limited
Dann, Dorfman, Herre & Skillman, P.C.
Nashed Nashaat T.
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