Hybrid plasminogen activator

Details Hybrid plasminogen activator Hybrid plasminogen activator

1994-06-06

1996-04-02

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

424 9464, 435226, C12N 950, C12N 964, A61K 3848, A61K 3849

Patent

active

055040012

ABSTRACT:
Hybrid proteins comprising a cross-linking domain derived from a protein that acts as an acyl-donor substrate for factor XIIIa, a fibrin-binding domain, and a serine protease domain are disclosed. Host cells transfected or transformed with an expression vector comprising a transcriptional promoter operably linked to a DNA sequence encoding such hybrid proteins are also disclosed, as well as methods for producing the proteins. The proteins may be utilized in combination with a suitable carrier or diluent as pharmaceutical compositions.

REFERENCES:
van Zonneveld et al. PNAS 83 4670-74 (Jul. 1986).
Verstraete et al. Blood 67(6) 1529-41 (Jun. 1986).
Tamaki et al. BBA 661 280-286 (1981).
Ichimose et al. FEBS Lett. 153(2) 369-71 (Mar. 1983).

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