Hybrid plasminogen activator

Details Hybrid plasminogen activator Hybrid plasminogen activator

1994-09-23

1996-12-03

Jacobson, Dian C.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9464, 435212, 435215, 435226, A61K 3849, C12N 948, C12N 972, C12N 964

Patent

active

055805590

ABSTRACT:
Novel single-chain hybrid plasminogen activators having an amino acid sequence composed of at least two subsequences corresponding in amino acid identity and number to subsequences of human t-PA and of human u-PA, and mutants thereof in which at least one of the N-glycosylation sites is modified such that glycosylation cannot take place at these sites exhibit valuable pharmacological properties. The hybrid plasminogen activators are produced by recombinant DNA technology.

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