Hybrid plasmid for 38 kDa antigen of M. tuberculosis

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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424 92, 4241841, 4241921, 4242031, 530350, 530412, 530413, 530417, 530418, 530422, 435 693, A61K 3904, A61K 3900, C07K 100, C07K 1600

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061104698

ABSTRACT:
The invention concerns a hybrid plasmid for the expression of unfused 38 kDa antigen of M. tuberculosis in E. coli, E. coli with the plasmid, an 38 kDa antigen and a protein of about 33 kDa useful for diagnoses.

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Singh et al. Gene 117(1):53-60 Aug. 1992.
McCarthy et al. Molecular Microbiology 2:455-65 1988.
Verbon et al. Scand. J. Immunol. 36:371-84 (Mar. 1992).
Schauder et al. Gene 52(1):279-83 1987.
Andersen et al. Infection and Immunity 57(8):2481-88 1989.
Young et al. Infection and Immunity 54(1): 177-83 1986.
Deres et al. Nature 342:561-564 1989.
Wiker et al. Journal of General Microbiology 137(4): 875-84 Apr. 1991.
Sambrook, J. Molecular Cloning, A Laboratory Manual, 2nd Edition pp. 17.37-17.41 1989.

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