Hybrid phthalocyanine derivatives and their uses

Details Hybrid phthalocyanine derivatives and their uses Hybrid phthalocyanine derivatives and their uses

2006-08-01

2006-08-01

Wang, Andrew (Department: 1639)

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

C436S800000, C540S122000, C427S219000

Reexamination Certificate

active

07083984

ABSTRACT:
Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit with a desired excitation peak; and (2) at least one acceptor subunit with a desired emission peak, wherein said derivative(s) is/are capable of intramolecular energy transfer from said donor subunit to said acceptor subunit. Such derivatives also may contain an electron transfer subunit. Axial ligands may be covalently bound to the metals contained in the water soluble hybrid phthalocyanine derivatives. Ligands, ligand analogues, polypeptides, proteins and nucleic acids can be linked to the axial ligands of the dyes to form dye conjugates useful in immunoassays and nucleic acid assays.

REFERENCES:
patent: 3996345 (1976-12-01), Ullman et al.
patent: 4166105 (1979-08-01), Hirschfeld
patent: 4199163 (1980-04-01), Nelson et al.
patent: 4199559 (1980-04-01), Ullman et al.
patent: 4326008 (1982-04-01), Rembaum
patent: 4368258 (1983-01-01), Fujiwhara et al.
patent: 4420568 (1983-12-01), Wang et al.
patent: 4434236 (1984-02-01), Freytag
patent: 4476229 (1984-10-01), Fino et al.
patent: 4510251 (1985-04-01), Kirkemo et al.
patent: 4542104 (1985-09-01), Stryer et al.
patent: 4609689 (1986-09-01), Schwartz et al.
patent: 4666862 (1987-05-01), Chan
patent: 4777128 (1988-10-01), Lippa
patent: 4803170 (1989-02-01), Stanton et al.
patent: 5039798 (1991-08-01), Johnson
patent: 5055414 (1991-10-01), Babb et al.
patent: 5089391 (1992-02-01), Buechler et al.
patent: 5116989 (1992-05-01), Hale et al.
patent: 5123731 (1992-06-01), Yoshinaga et al.
patent: 5132206 (1992-07-01), Dreyer
patent: 5135717 (1992-08-01), Renzoni et al.
patent: 5154887 (1992-10-01), Babb et al.
patent: 5157412 (1992-10-01), Kleinschmidt et al.
patent: 5187288 (1993-02-01), Kang et al.
patent: 5194393 (1993-03-01), Hugl et al.
patent: 5248782 (1993-09-01), Haugland et al.
patent: 5254887 (1993-10-01), Oguri
patent: 5274113 (1993-12-01), Kang et al.
patent: 5326692 (1994-07-01), Brinkley et al.
patent: 5428152 (1995-06-01), Hayashida et al.
patent: 5460646 (1995-10-01), Lazzouni et al.
patent: 5473928 (1995-12-01), Teitzel
patent: 5484685 (1996-01-01), Tai et al.
patent: 5624028 (1997-04-01), Shin et al.
patent: 6238931 (2001-05-01), Buechler et al.
patent: 0075982 (1983-04-01), None
patent: 0076695 (1983-04-01), None
patent: 0076992 (1983-04-01), None
patent: 0285965 (1988-10-01), None
patent: 0407138 (1991-01-01), None
patent: 0407188 (1991-01-01), None
patent: 0597389 (1994-05-01), None
patent: 0597389 (1994-06-01), None
patent: 880477 (1988-06-01), None
patent: 8804777 (1988-06-01), None
patent: 880477 (1989-06-01), None
patent: 9118007 (1991-11-01), None
patent: 9319366 (1993-09-01), None
patent: 9323492 (1993-11-01), None
patent: 9508772 (1995-03-01), None
Sounik et al (EPO 0391284 A1) (Date of Publication is Oct. 10, 1990).
Wheeler, B. L.; Nagasubramanian, G.; Bard, A. J.; Schechtman, L. A.; Dininny, D. R.; Kenney, M. E. J. Am. Chem. Soc. 1984, 106, 7404-7410).
Vener, T. I.; Turchinskii, M. F.; Knorre, V. D.; Lukin, Y. V.; Shcherbo, S. N.; Zubov, V. P.; Sverdlov, E. D. “A novel approach to nonradioactive hybridization assay of nucleic acids sing stainted latex particles” Analytical Biochemistry 1991, 198(2), 308.
Ben-Hur, E., et al. “Phthalocyanine-Induced Photohemolysis: Structure-Activity Relationship and The Effect of Fluoride,”Photochemistry and Photobiology58; No. 3, 351-355 (1993).
Kudrevich, et al. “Syntheses of Monosulfonated Phthalocyanines, Benzonaphthoporphyrazines and Porphyrins via the Meerwein Reaction,”Journal of The Chemical Society: Perkin Transactions2767-2774 (1994).
Margaron, P. et al. “Photodynamic Properties of Naphthosulfobenzoporphyrazine Derivatives,”Journal of Photochemistry and Photobiology14:187-199 (1992).
Margaron, P. et al. “Chromatographic Analysis of Asymmetric Sulphophthalocyanines Using a Diode-arry Detector,”Journal of Chromotography634: 57-64 (1993).
Hemnila, Clin. Chem. 31/3 359-370 (1985) “Fluoro immunoassays and Immunofluorometric Assays”.
Pekcan, O. et al, “Direct Energy Transfer Studies on Doped and Labelled Polymer Lasex Particles”Physical Review Letters81:641-644 (Aug. 1, 1998).
Stryer, Lubert, “Fluorescent Energy Transfer As A Spectroscopic Ruler”Ann. Rev. Nechem.47:818-48 (1978).
Molecular Probes Ad entitled “Novel Fluorescent Latex Microspheres—Transluosphores A Breakthrough in Latex Microsphere Technology (1984)”.
Wheeler, B.L. et al., “A Silicon Phthalocyanina: Synthesis, Electrochemistry, and Electrogenerated Chemiluminescence,”J. Am. chem. Soc.106:7404-7410 91984).
Cerfontain and Kort, “Electrophilic Aromatic Sulfonation with Acidic Sulfonating Reagent,”Int. l. Sulfur Chem.C6:123-136 (1971).
Cerfontain and Kort,Mechanistic Aspects in Aromatic Sulfonation and Desulfonation, Interscience, New York, pp. 2-5, 68-79 and 121-126 (1968).
Cook et al., “Octa-alkosy Phthalocyanine and Naphthalocyanine Derivatives: Dyes with Q-Band Absorption in the Far Red or Near Infrared,”I. Chem. Soc. Perkin. Trans. I.pp. 2453-2458 (1988).
Eldred and Young, “Dichloralymaric Acid,”I. Am. Chem. Soc.75:4338-4339 (1953).
Förster, “Zwischeomolekulare Energiewanderung und Fluoreszenz,”Ann. Physik,2:55-75 (1948).
Gilbert,Sulfonation and Related Reactions, Interscience, New York, pp. 102-103, 306-307 and 339-383 (1965).
Gregoriadis (editor),Liposome Technology, vol. III, CRC Press Inc., p. 19 (1984).
Haughland et al., “Dependence of the Kinetics of Siinglet-Singlet Energy Transfer on Spectral Overlap,”Proc. Natl. Acad. Sci. USA63:23-30 (1969).
Haughland, “Potential Sensitive Probes,”Handbook of Fluorescent Probes and Research Chemicals, 5th edition, Molecular Probes, Inc., pp. 156-158 (1992-1994).
Hemmila,Applications of iluorescence in immunoassays, John Wiley & Sons, Inc., pp. 131-135 (1991).
Ikeda et al., “Synthesis of Non-Symmetrically Benzo-Substituted Phthalocyanines and Their Electronic Spectra,”Chemistry Letterspp. 763-766 (1992).
Kirby and Gregoriadis, “Ch. 2—A Simple Procedure For Preparing Liposomes Capable of High Encapsulation Efficiency Under Mild Conditions,”Liposome Technology, vol. 1, Gregoriadis editor, CRC Press Inc., pp. 20-26 (1984).
Kobayashi et al., “Synthesis, Spectroscopy, Electrochemistry and Spectroelectrochemistry of a Zinc Phthalocyanine with D1, Symmetry,”Chemistry Letterspp. 2031-2034 (1992).
Kobayashi et al., “Benzene or Naphthalene Ring-fused Alone-Substituted Type Tetraazaoctaphenylporphyrin Zinc Complexes,”Chemistry Letterspp. 1567-1570 (1992).
Kobayashi et al., “new Route to Unsymmetrical Phtalocyanine Analogues by the Use of Structurally Distorted Subphthalocyanines,”I. Am. Chem. Soc.112:9640-9641 (1990).
Kobayashi et al., “Phtalocyanines of a Novel Structure: Dinaphtholetraazaporphyrins with O1, Symmetry,”Inorg. Chem.33:1735-1740 (1994).
Xonami et al., “Electronic spectra of benzo-substited phthalocyanines,”Molecular Physics80:153-160 (1993).
Mayhew et al., “Ch. 2—Preparation of Liposomes Entrapping Cancer Chemtherapeutic Agents for Experimental In Vivo and In Vitro Studies,”Liposome Technology, vol. 11, Gregoriadis editor, CRC Press Inc., pp. 19-31 (1984).
McHugh and Gouterman, “Porphyrins XXIV. Energy, Oscillator Strength, and Zeeman Splitting Calculations (SCMO-Ct) for Phthalocyanine, Prophyrins, and Related Ring Systems,”Theoret. Chem. Acta(Berlin) 24:346-370 (1972).
Mikhalenko et al., “Pthalocyanines and Related Compounds,”I. Org. Chem.(USSR English Translation) 8:341-343 (1972).
Pariser et al., “A Semi-Empirical Theory of the Electronic Spectra and Electronic Structure of Complex Unsaturated Molecules. II,”I. Chem. Phys:21:767-776 (1953).
Pople, “Elect

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