Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-03-22
1998-10-20
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
540122, C09B 4700, C09B 4730, C07D48722
Patent
active
058247998
ABSTRACT:
Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit with a desired excitation peak; and (2) at least one acceptor subunit with a desired emission peak, wherein said derivative(s) is/are capable of intramolecular energy transfer from said donor subunit to said acceptor subunit. Such derivatives also may contain an electron transfer subunit. Axial ligands may be covalently bound to the metals contained in the water soluble hybrid phthalocyanine derivatives. Ligands, ligand analogs, polypeptides, proteins and nucleic acids can be linked to the axial ligands of the dyes to form dye conjugates useful in immunoassays and nucleic acid assays.
REFERENCES:
patent: 3996345 (1976-12-01), Ullman et al.
patent: 4166105 (1979-08-01), Hirschfield
patent: 4199363 (1980-04-01), Chen
patent: 4199559 (1980-04-01), Ullman et al.
patent: 4326008 (1982-04-01), Rembaum
patent: 4368258 (1983-01-01), Fujiwhara et al.
patent: 4420568 (1983-12-01), Wang et al.
patent: 4476229 (1984-10-01), Fino et al.
patent: 4510251 (1985-04-01), Kirkemo et al.
patent: 4542104 (1985-09-01), Stryer et al.
patent: 4609689 (1986-09-01), Schwartz et al.
patent: 4666862 (1987-05-01), Chan
patent: 4777128 (1988-10-01), Lippa
patent: 5039798 (1991-08-01), Johnson
patent: 5055414 (1991-10-01), Babb et al.
patent: 5089391 (1992-02-01), Buechler et al.
patent: 5116989 (1992-05-01), Hale et al.
patent: 5123731 (1992-06-01), Yoshinaga et al.
patent: 5132206 (1992-07-01), Dreyer
patent: 5154887 (1992-10-01), Babb
patent: 5157412 (1992-10-01), Kleinschmidt et al.
patent: 5187288 (1993-02-01), Kang et al.
patent: 5194393 (1993-03-01), Hugh et al.
patent: 5248782 (1993-09-01), Haughland et al.
patent: 5274113 (1993-12-01), Kang et al.
patent: 5326692 (1994-07-01), Brinkley et al.
patent: 5403928 (1995-04-01), Arrhenuis
patent: 5428152 (1995-06-01), Hayashida et al.
patent: 5484685 (1996-01-01), Tai et al.
Cerfontain and Kort, "Electrophilic Aromatic Sulfonation with Acidic Sulfonating Reagent," Int. J. Sulfur Chem. C6:123-136 (1971).
Cerfontain and Kort, Mechanistic Aspects in Aromatic Sulfonation and Desulfonation, Interscience, New York, pp. 2-5, 68-79 and 121-126 (1968).
Cook et al., "Octa-alkoxy Phthalocyanine and Naphthalocyanine Derivatives: Dyes with Q-Band Absorption in the Far Red or Near Infrared," J. Chem. Soc. Perkin Trans. I pp. 2453-2458 (1988).
Eldred and Young, "Dichlorofumaric Acid," J. Am. Chem. Soc. 75:4338-4339 (1953).
Forster, "Zwischenmolekulare Energiewanderung und Fluoreszenz," Ann. Physik. 2:55-75 (1948).
Gilbert, Sulfonation and Related Reactions, Interscience, New York, pp. 102-103, 306-307 and 339-383 (1965).
Gregoriadis (editor), Liposome Technology, vol. III, CRC Press Inc., p. 19 (1984).
Haughland et al., "Dependence of the Kinetics of Singlet-Singlet Energy Transfer on Spectral Overlap," Proc. Natl. Acad. Sci. USA 63:23-30 (1969).
Haughland, "Potential Sensitive Probes," Handbook of Fluorescent Probes and Research Chemicals, 5th edition, Molecular Probes, Inc., pp. 156-158 (1992-1994).
Hemmila, Applications of fluorescence in immunoassays, John Wiley & Sons, Inc., pp. 131-135 (1991).
Ikeda et al., "Synthesis of Non-Symmetrically Benzo-Substituted Phthalocyanines and Their Electronic Spectra,"0 Chemistry Letters pp. 763-766 (1992).
Kirby and Gregoriadis, "Ch. 2--A Simple Procedure For Preparing Liposomes Capable of High Encapsulation Efficiency Under Mild Conditions," Liposome Technology, vol. I, Gregoriadis editor, CRC Press Inc., pp. 20-26 (1984).
Kobayashi et al., "Synthesis, Spectroscopy, Electrochemistry and Spectroelectrochemistry of a Zinc Phtalocyanine with D.sub.2h Symmetry," Chemistry Letters pp. 2031-2034 (1992).
Kobayashi et al., "Benzene or Naphthalene Ring-fused Mono-Substituted Type Tetraazaoctaphenylporphyrin Zinc Complexes," Chemistry Letters pp. 1567-1570 (1992).
Kobayashi et al., "New Route to Unsymmetrical Phtalocyanine Analogues by the Use of Structurally Distorted Subphtalocyanines," J. Am. Chem. Soc. 112:9640-9641 (1990).
Kobayashi et al., "Phtalocyanines of a Novel Structure: Dinaphthotetraazaporphyrins with D.sub.2h Symmetry," Inorg. Chem. 33:1735-1740 (1994).
Konami et al., "Electronic spectra of benzo-substituted phthalocyanines," Molecular Physics 80:153-160 (1993).
Mayhew et al., "Ch. 2--Preparation of Liposomes Entrapping Cancer Chemtherapeutic Agents for Experimental In Vivo and In Vitro Studies," Liposome Technology, vol. II, Gregoriadis editor, CRC Press Inc., pp. 19-31 (1984).
McHugh and Gouterman, "Porphyrins XXIV. Energy, Oscillator Strength, and Zeeman Splitting Calculations (SCMO-CI) for Phthalocyanine, Prophyrins, and Related Ring Systems," Theoret. Chim. Acta (Berlin) 24:346-370 (1972).
Mikhalenko et al., "Pthalocyanines and Related Compounds," J. Org. Chem. (USSR (English Translation) 8:341-343 (1972).
Molecular Probes Ad entitled "Novel Fluorescent Latex Microspheres--Transfluospheres a Breakthrough in Latex Microsphere Technology" (1994).
Pariser et al., "A Semi-Empirical Theory of the Electronic Spectra and Electronic Structure of Complex Unsaturated Molecules. II," J. Chem. Phys. 21:767-776 (1953).
Pekcan et al., "Energy-Transfer Studies on Doped and Labeled Polymer Latex Particles," Physical Review Letters 61:641-644 (1988).
Pople, "Electron Interaction in Unsaturated Hydrocarbons," Trans. Faraday Soc. 49:1375-1385 (1953).
Stryer, "Fluorescence Energy Transfer as a Spectroscopic Ruler," Annual Review of Biochemistry 47:819-846 (1978).
Van Arman et al., "General Fluorescence Assay for Enzyme-Catalyzed Polyanion Hydrolysis Based on Template-Directed Excimer Formation. Application to Heparin and Polyglutamate," J. Am. Chem. Soc. 112:5376-5377 (1990).
Wheeler et al., "A Silicon Phthalocyanine and Silicon Napthalocyanine: Synthesis, Electrochemistry and Electrogenerated Chemiluminescence," J. Am. Chem. Soc. 106:7404-7410.
Buechler Kenneth F.
Noar Joseph B.
Tadesse Lema
Biosite Diagnostics Incorporated
Shah Mukund J.
Sripada Pavanaram K.
LandOfFree
Hybrid phthalocyanine derivatives and their uses does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hybrid phthalocyanine derivatives and their uses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hybrid phthalocyanine derivatives and their uses will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-245557