Hybrid peptides modulate the immune response

Details Hybrid peptides modulate the immune response Hybrid peptides modulate the immune response

2007-04-04

2009-06-02

Saunders, David A. (Department: 1644)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S012200, C514S013800, C424S184100, C424S185100, C424S192100, C424S193100

Reexamination Certificate

active

07541334

ABSTRACT:
The present invention provides an MHC class II antigen presentation enhancing hybrid polypeptide. The hybrid has an N-terminus comprising the mammalian Ii key peptide LRMKLPKPPKPVSKMR (SEQ ID NO: 1) and modifications thereof which retain antigen presentation enhancing activity, a C-terminus comprising an antigenic epitope in the form of a polypeptide or peptidomimetic structure which binds to the antigenic peptide binding site of an MHC class II molecule, and an intervening chemical structure covalently linking the N-terminal and C-terminal components.

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