Hybrid peptides modulate the immune response

Details Hybrid peptides modulate the immune response Hybrid peptides modulate the immune response

2007-04-17

2007-04-17

Chan, Christina (Department: 1644)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S012200, C514S013800, C424S184100, C424S185100, C424S192100, C424S193100

Reexamination Certificate

active

10197000

ABSTRACT:
The present invention provides an MHC class II antigen presentation enhancing hybrid polypeptide. The hybrid has an N-terminus comprising the mammalian Ii key peptide LRMKLPKPPKPVSKMR (SEQ ID NO: 1) and modifications thereof which retain antigen presentation enhancing activity, a C-terminus comprising an antigenic epitope in the form of a polypeptide or peptidomimetic structure which binds to the antigenic peptide binding site of an MHC class II molecule, and an intervening chemical structure covalently linking the N-terminal and C-terminal components.

REFERENCES:
patent: 5559028 (1996-09-01), Humphreys
patent: 5827516 (1998-10-01), Urban et al.
patent: 5919639 (1999-07-01), Humphreys et al.
patent: WO 98/37178 (1998-08-01), None
Adams and Humphreys, Eur. J. Immunol. 25: 1693-1702 (1995).
Adams et al., Arzneim.-Forsch./Drug Res. 47: 1069-1077 (1997).
Stern et al., Nature 378: 215-221 (1994).
Ghosh et al., Nature 378: 457-462 (1995).
Xu et al., Arzneim.-Forsch./Drug Res. 49: 791-799 (1999).
Sanderson et al., PNAS 92: 7217-7221 (1995).

Affiliated with

Also associated with

Rating

Hybrid peptides modulate the immune response does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hybrid peptides modulate the immune response, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hybrid peptides modulate the immune response will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3791277