Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Combination of antigens from multiple viral species
Patent
1998-08-10
1999-10-12
Woodward, Michael P.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Combination of antigens from multiple viral species
4241921, 4242271, 435 693, 435 699, 536 2372, A61K 39295, C12N 1533, C07H 2104
Patent
active
059651407
ABSTRACT:
Novel immunogenic compositions are provided involving viral particles composed at least in part of hybrid proteins of at least a portion of a particle forming protein and one or more polypeptides having at least one epitope of interest. Nucleic acid sequences are employed coding for the hybrid protein which are introduced into a host cell for expression, either by themselves or in combination with other DNA sequences coding for particle forming proteins. Expression of the DNA sequences results in formation of particles which may be isolated and used as immunogens for production of antibodies for diagnostics purposes, passive immunization, vaccination, or other uses.
Saccharomyces carlsbergensis, 2150-2-3 (pDC103), was deposited on Sep. 7, 1984, at the ATCC and given ATCC Accession No. 20726. Also, Saccharomyces cerevisiae PO17 (pCl/l-MCS29) was deposited at the ATCC on Sep. 5, 1985, and given ATCC Accession No. 20770.
REFERENCES:
patent: 4710463 (1987-12-01), Murray et al.
Ballou et al., "Immunogenicity of Synthetic Peptides From Circumsporozoite Protein of Plasmodium Falciparum," Science 228:996 (1985).
Bouges-Bocquet et al., Chemical Abstracts 101:185169g(1984).
Dame et al., "Structure of the Gene Encoding the Immunodominant Surface Antigen on Sporozoite of the Human Malaria Parasite Plasmodium Falciparum," Science 225: p. 593 (1984).
Edman et al., "Synthesis of Hepatitis B Surface and Core Antigens in E. Coli", Nature 291:503-506 (1981).
Enea et al., "DNA Cloning of Plasmodium Falciparum Circumsporozoite Gene: Amino Acid Sequence of Repetitive Epitope," Science 225:628 (1984).
Sharma and Godson, "Expression of the Major Surface Antigen of Plasmodium Knowlesi Sporozoites in Yeast," Science 228:879 (1985).
Valenzuela, P., et al., "The Nucleotide Sequence of the Hepatitis B Viral Genome and the Identification of the Major Viral Genes," Animal Virus Genetics pp. 57-70 (1980).
Valenzuela, P., et al., "Synthesis and Assembly of Hepatitis B Virus Surface Antigen Particles in Yeast," Nature 298:347-350 (1982).
Valenzuela, P., et al., "Antigen Engineering in Yeast: Synthesis and Assembly of Hybrid Hepatitis B Surface Antigen-Herpes Simplex 1 gD Particles," Bio/Technology 3:323-326 (1985).
Valenzuela, P., et al., "Nucleotide Sequence of the Gene Coding for the Major Protein of Hepatitis B Virus Surface Antigen," Nature 280:815-819 (1979).
Watson R.J., et al., "Herpes Simplex Virus Type-1 Glycoprotein D Gene: Nucleotide Sequence and Expression in Escherichia Coli," Science 218:381-384 (1982).
Young et al., "Expression of Plasmodium Falciparum Circumsporozoite Proteins in Escherichia Coli for Potential use in a Human Malaria Vaccine," Science 228:958 (1985).
Barr Philip J.
Kuo George
Valenzuela Pablo D. T.
Blackburn Robert P.
Chiron Corporation
Harbin Alisa A.
Robins Roberta L.
Woodward Michael P.
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